Abstract
AFTER contact with an antigen in vitro, lymphocytes from guinea-pigs showing delayed hypersensitivity against this antigen release a soluble factor which interferes with the migration of normal guinea-pig macrophages from the capillary tube in which they are cultured (migration inhibitory factor, MIF)1,2. This phenomenon has been considered as an in vitro model of delayed hypersensitivity3. Lymphocytes can also be stimulated by other factors such as phytohaemagglutinin (PHA) and antilymphocyte serum (ALS)6,7. In addition to releasing MIF, sensitized lymphocytes cultured in the presence of the specific antigen undergo blast transformation, an increase in DNA synthesis and mitosis4,5. It is not clear whether blast transformation and MIF releases are related phenomena8, but both may belong to the same sequence of cellular events, triggered by the binding of the “stimulating agent” to lymphocyte membranes.
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LAMELIN, J., VASSALLI, P. Inhibition of Macrophage Migration by a Soluble Factor from Lymphocytes stimulated with PHA or ALS. Nature 229, 426–428 (1971). https://doi.org/10.1038/229426a0
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DOI: https://doi.org/10.1038/229426a0
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