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Concentrations of Plasma Testosterone in Normal Men during Sleep


IN man, several studies1,2 have demonstrated diurnal variation, with a morning peak, in plasma testosterone—the most potent naturally occurring androgen. The origin of this variation is not known.

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  1. 1

    Dray, F., Reinberg, A., and Sebacun, J., CR Hebd. Seanc. Acad. Sci., 261, 573 (1965).

    CAS  Google Scholar 

  2. 2

    Resko, J. A., and Eik-ness, K. B., J. Clin. Endocrinol., 26, 573 (1966).

    CAS  Article  Google Scholar 

  3. 3

    Weitzman, E. D., Schaumburg, H., and Fishbein, W., J. Clin. Endocrinol., 26, 121 (1966).

    CAS  Article  Google Scholar 

  4. 4

    Weitzman, E. D., Goldmacher, D., Kripke, D., MacGregor, P., Kream, J., and Hellman, L., Trans. Amer. Neurol. Assoc., 93, 153 (1968).

    CAS  Google Scholar 

  5. 5

    Taka Hashi, Y., Kipnis, D. M., and Daughaday, W. H., J. Clin. Invest., 47, 2079 (1968).

    CAS  Article  Google Scholar 

  6. 6

    Sassin, J. F., Parker, D. C., Johnson, L. C., Rossman, L. G., Mace, J. W., and Gotlin, R. W., Life Sci., 8, 1299 (1969).

    CAS  Article  Google Scholar 

  7. 7

    Nieschlag, E., and Ismail, A. A. A., Klin. Wschr., 48, 53 (1970).

    CAS  Article  Google Scholar 

  8. 8

    Evans, J. I., Lewis, S. A. L., Gibb, I. A. M., and Cheetham, M., Brit. Med. J., 4, 291 (1968).

    CAS  Article  Google Scholar 

  9. 9

    Vankirk, K., and Sassin, J. F., Amer. J. E.E.G. Techn., 9, 143 (1969).

    Article  Google Scholar 

  10. 10

    Rechtschaffen, A., and Kales, A., Manual of Standardized Terminology (Pub. Health Serv., US Govt. Printing Office, Washington, DC, 1968).

    Google Scholar 

  11. 11

    Ismail, A. A. A., Love, D. N., and Nieschlag, E., Res. Steroids, 4, (in the press).

  12. 12

    Oswald, I., Prog. Brain Res., 18, 162 (1965).

    Google Scholar 

  13. 13

    Oswald, I., New Sci., 23, 170 (1970).

    Google Scholar 

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EVANS, J., MACLEAN, A., ISMAIL, A. et al. Concentrations of Plasma Testosterone in Normal Men during Sleep. Nature 229, 261–262 (1971).

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