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Proposed Mechanism for the Biological Assembly of Collagen Triple Helix

Abstract

If the three polypeptide chains of collagen had terminal segments with structures which facilitated rapid association and were then discarded, a puzzle might be solved. Such a mechanism could explain why biosynthesis of collagen takes minutes in vivo but much longer in vitro.

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SPEAKMAN, P. Proposed Mechanism for the Biological Assembly of Collagen Triple Helix. Nature 229, 241–243 (1971). https://doi.org/10.1038/229241a0

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