Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

L-Asparaginase and Human Malignant Disease

Abstract

The enzyme L-asparaginase, which breaks down asparagine, causes certain tumours to regress. This property has been put to use in the treatment of malignant disease in man.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kidd, J. G., J. Exp. Med., 98, 565 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kidd, J. G., J. Exp. Med., 98, 583 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Broome, J. D., Nature, 191, 1114 (1961).

    Article  ADS  CAS  Google Scholar 

  4. Broome, J. D., J. Exp. Med., 118, 99 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Broome, J. D., J. Exp. Med., 118, 121 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Clementi, A., Arch. Intern. Physiol., 19, 369 (1922).

    CAS  Google Scholar 

  7. Holmquist, N. D., Fed. Proc., 21, 166 (1962).

    Google Scholar 

  8. Old, L. J., Boyse, E. A., Campbell, H. A., and Daria, G. M., Nature, 198, 801 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Ohnuma, T., Bergel, R., and Bray, R. C., Biochem. J., 103, 238 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mashburn, L. T., and Wriston, J. C., Arch. Biochem., 105, 451 (1964).

    Article  Google Scholar 

  11. Roberts, J., Prager, M. D., and Bachynsky, N., Cancer Res., 26, 2213 (1966).

    CAS  PubMed  Google Scholar 

  12. Schwartz, J. H., Reeves, J. Y., and Broome, J. D., Proc. US Nat. Acad. Sci., 56, 1516 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Campbell, H. A., Mashburn, L. T., Boyse, E. A., and Old, L. J., Biochemistry, 6, 721 (1967).

    Article  CAS  PubMed  Google Scholar 

  14. Broome, J. D., J. Nat. Cancer Inst., 35, 967 (1965).

    CAS  PubMed  Google Scholar 

  15. Schwartz, M. K., Lash, E. D., Oettgen, H. F., and Tomao, F. A., Cancer, 25, 244 (1970).

    Article  CAS  PubMed  Google Scholar 

  16. Boyse, E. A., Old, L. J., Campbell, H. A., and Mashburn, L. T., J. Exp. Med., 125, 17 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Jameson, E., Ainis, H., and Ryan, R. M., Science, 124, 980 (1956).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Haley, E. E., Fischer, G. A., and Welch, A. D., Cancer Res., 21, 532 (1961).

    CAS  PubMed  Google Scholar 

  19. Kwak, K. S., Jameson, E., Ryan, R. M., and Kurtz, H. M., Cancer Res., 21, 44 (1961).

    CAS  PubMed  Google Scholar 

  20. Old, L. J., Boyse, E. A., Campbell, H. A., Brodey, R. S., Fidler, J., and Teller, J. D., Cancer, 20, 1066 (1967).

    Article  CAS  PubMed  Google Scholar 

  21. Sobin, L. H., and Kidd, J. G., Proc. Soc. Exp. Biol. and Med., 119, 325 (1965).

    Article  CAS  Google Scholar 

  22. Sobin, L. H., and Kidd, J. G., J. Exp. Med., 123, 55 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Patterson, jun., M. K., and Orr, G. R., Biochem. Biophys. Res. Commun., 26, 228 (1967).

    Article  CAS  PubMed  Google Scholar 

  24. Broome, J. D., and Schwartz, J. H., Biochim. Biophys. Acta., 138, 637 (1967).

    Article  CAS  PubMed  Google Scholar 

  25. Patterson, jun., M. K., and Orr, G. R., J. Biol. Chem., 243, 376 (1968).

    CAS  PubMed  Google Scholar 

  26. Prager, M. D., and Bachynsky, N., Biochem. Biophys. Res. Commun., 31, 43 (1968).

    Article  CAS  PubMed  Google Scholar 

  27. Horowitz, B., Madras, B., Meister, A., Old, L. J., Boyse, E. A., and Stockert, E., Science, 160, 533 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Broome, J. D., J. Exp. Med., 127, 1055 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Oettgen, H. F., Old, L. J., Boyse, E. A., Campbell, H. A., Philips, F. S., Clarkson, B. D., Tallal, L., Leeper, R. D., Schwartz, M. K., and Kim, J. H., Cancer Res., 27, 2619 (1967).

    CAS  PubMed  Google Scholar 

  30. Oettgen, H. F., and Schulten, H. K., Klin. Wochensch., 47, 65 (1969).

    Article  CAS  Google Scholar 

  31. Haskell, C. M., Leventhal, B. G., Paul, M. R., and Canellos, G. P., Cancer Res., 29, 974 (1969).

    CAS  PubMed  Google Scholar 

  32. Hill, J. M., Roberts, J., Loeb, E., Kahn, A., MacLellan, A. and Hill, R. W., J. Amer. Med. Assoc., 202, 882 (1967).

    Article  CAS  Google Scholar 

  33. Becker, F. F., and Broome, J. D., Science, 156, 1602 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Ohno, R., and Hersh, E. M., Blood, 35, 250 (1970).

    CAS  PubMed  Google Scholar 

  35. Hill, J. M., Loeb, E., MacLellan, A., Hill, N. O., Khan, A., and Speer, R. J., Proc. Thirteenth Intern. Cong. Haematol., Munich, 95 (1970).

  36. Adamson, R. H., Proc. Amer. Assoc. Cancer Res., 9, 2 (1968).

    Google Scholar 

  37. Dolowy, W. C., Henson, D., Cornet, J., and Sellin, H., Cancer, 19, 1813 (1966).

    Article  CAS  PubMed  Google Scholar 

  38. Hill, J. M., Roberts, J., Loeb, E., Khan, A., MacLellan, A., and Hill, R. W., J. Amer. Med. Assoc., 202, 882 (1967).

    Article  CAS  Google Scholar 

  39. Schwartz, M. K., Lash, E. D., Oettgen, H. F., and Tomao, F. A., Cancer, 25, 244 (1970).

    Article  CAS  PubMed  Google Scholar 

  40. Tallal, L., Tan, C., Oettgen, H., Wollner, N., McCarthy, M., Helson, L., Burchenal, J., Karnofsky, D., and Murphy, M. L., Cancer, 25, 306 (1970).

    Article  CAS  PubMed  Google Scholar 

  41. Clarkson, B., Krakoff, I., Burchenal, J., Karnofsky, D., Golbey, R., Dowling, M., Oettgen, H., and Lipton, A., Cancer, 25, 279 (1970).

    Article  CAS  PubMed  Google Scholar 

  42. Hill, J. M., Loeb, E., MacLellan, A., Khan, A., Roberts, J., Shields, W. F., and Hill, N. O., Cancer Res., 29, 1547 (1969).

    Google Scholar 

  43. Burchenal, J. H., Dowling, jun., M. D., and Tan, C. T. C., Proc. Thirteenth Intern. Cong. Haematol., Munich, 94 (1970).

  44. Capizzi, R. L., Summers, W. P., and Bertino, J. R., Proc. Amer. Assoc. Cancer Res., 11, 14 (1970).

    Google Scholar 

  45. Crowther, D., Bateman, C. J. T., Vartan, C. P., Whitehouse, J. M. A., Malpas, J. S., Hamilton Fairley, G., and Bodley Scott, R., Brit. Med. J., 4, 513 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Rausen, A. R., and Glidewell, O. J., for Acute Leukaemia Group B, Proc. Thirteenth Intern. Cong. Haematol., Munich, 94 (1970).

  47. Haskell, C. M., Canellos, C. P., Leventhal, B. G., Carbone, P. P., Serpick, A. A., and Hansen, H. H., Cancer Res., 29, 974 (1969).

    CAS  PubMed  Google Scholar 

  48. Beard, M. E. J., Crowther, D., Galton, D. A. G., Guyer, R. J., Hamilton Fairley, G., Kay, H. E. M., Knapton, P. J., Malpas, J. S., and Bodley Scott, R., Brit. Med. J., 1, 191 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Oettgen, H. F., Stevenson, P. A., Schwartz, M. K., Leeper, R. D., Tallal, L., Tan, C. T. C., Clarkson, B. D., Golbey, R. B., Krakoff, L. H., Karnofsky, D. A., Murphy, M. L., and Burchenal, J. H., Cancer, 25, 253 (1970).

    Article  CAS  PubMed  Google Scholar 

  50. Schwartz, R. S., Nature, 224, 275 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CROWTHER, D. L-Asparaginase and Human Malignant Disease. Nature 229, 168–171 (1971). https://doi.org/10.1038/229168a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/229168a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing