Abstract
NEW interest is being shown in the nature of the metabolites of vitamin D, particularly those found in the target tissues, and in the part they play in controlling Ca2+ metabolism1–4. The first to be identified was 25-hydroxy-cholecalciferol (25-HCC) which is 1.4 times more potent than cholecalciferol itself2 and which we have shown to be converted to a more polar metabolite, not yet fully characterized. Experiments with [l-3H,4-14C] cholecalciferol indicated that all the 3H is lost during the formation of this metabolite. This suggests that there is an oxygen function at C-l as well as at C-3 and C-25 (refs 3 and 4). Contrary to the original reports5, it is this metabolite (designated compound P) and not 25-HCC that is found in the intestinal nuclei of chicks. The intestine is the richest source of compound P, although it is also found in other tissues, particularly kidney, bone, liver and muscle3,4.
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References
Haussler, M. R., Myrtle, J. F., and Norman, A. W., J. Biol. Chem., 243, 4055 (1968).
DeLuca, H. F., Fed. Proc., 28, 1678 (1969).
Lawson, D. E. M., Wilson, P. W., and Kodicek, E., Nature, 222, 171 (1969).
Lawson, D. E. M., Wilson, P. W., and Kodicek, E., Biochem. J., 115, 269 (1969).
Blunt, J. W., DeLuca, H. F., and Schnoes, H. K., Biochemistry, 7, 3317 (1968).
Norman, A. W., Amer. J. Physiol., 211, 829 (1966).
Myrtle, J. F., Haussler, M. B., and Norman, A. W., J. Biol. Chem, 245, 1190 (1970).
Wales, F. W., J. Biol. Chem., 204, 577 (1953).
Trummel, C. L., Raisz, L. G., Blunt, J. W., and DeLuca, H. F., Science, 163, 1450 (1969).
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KODICEK, E., LAWSON, D. & WILSON, P. Biological Activity of a Polar Metabolite of Vitamin D3. Nature 228, 763–764 (1970). https://doi.org/10.1038/228763a0
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DOI: https://doi.org/10.1038/228763a0
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