Abstract
THE possibility that the invasiveness of malignant tissues may result from collagenolytic action of tumour cells was early considered1–3. This idea, however, was not supported by subsequent efforts to isolate a specific enzyme from neoplastic tissues or by attempts to obtain lysis of collagen enclosed in perfusion chambers embedded in tumour bearing animals4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gersh, I., and Catchpole, H. R., Amer. J. Anat., 85, 457 (1949).
Sylven, B., and Malmgren, H., Acta Radiol. Suppl., 154, 1 (1957).
Grabowska, M., Nature, 183, 1186 (1959).
Shelton, E., J. Nat. Cancer Inst., 32, 709 (1964).
Gross, J., and Lapiere, C. M., Proc. US Nat. Acad. Sci., 48, 1014 (1962).
Eisen, A. Z., and Gross, J., Dev. Biol., 12, 408 (1965).
Fullmer, H. M., and Gibson, W., Nature, 209, 728 (1966).
Grillo, H. C., and Gross, J., Dev. Biol., 15, 300 (1967).
Fullmer, H. M., Gibson, W. A., Lazarus, G. S., Bladen, H. A., and Whedon, K. A., J. Dent. Res. Suppl., 48, 646 (1969).
Lazarus, G. S., Fullmer, H. M., Oliver, C. H., Multz, C. V., Barth, W. F., Decker, J. L., and Kamin, E. J., Proc. Fourth Panamerican Cong. Rheumatol. New York (Exerpta Medica Foundation, Amsterdam, 1967).
Riley, W. B., and Peacock, E. E., Proc. Soc. Exp. Biol. Med., 124, 207 (1967).
Bornstein, M. B., Lab. Invest., 7, 1234 (1958).
Rose, G. G., Pomerat, C. M., Shindler, T. O., and Trunnell, J. B., J. Biophys. Biochem. Cytol., 4, 761 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TAYLOR, A., LEVY, B. & SIMPSON, J. Collagenolytic Activity of Sarcoma Tissues in Culture. Nature 228, 366–367 (1970). https://doi.org/10.1038/228366a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/228366a0
This article is cited by
-
Matrix metalloproteinase inhibitors in the treatment of cancer
Medical Oncology (1997)
-
Tumor invasion and host extracellular matrix
CANCER AND METASTASIS REVIEW (1983)
-
Role of collagenases in tumor cell invasion
Cancer and Metastasis Review (1982)
-
Collagenolytic activity of eosinophilic granuloma in vitro
Experientia (1979)
-
Changes in the collagenolytic activity released by primary VX-2 carcinoma cultures as a function of tumor growth
Molecular and Cellular Biochemistry (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
