Detection and Identification of Monoamine Oxidase Inhibitors in Biological Samples

Abstract

THE monoamine oxidase (MAO) inhibitor drugs are now widely used in psychiatric practice for the management of various types of neurotic and psychotic depressions; unfortunately, these therapeutically valuable drugs are implicated in an increasing number of severe and some times fatal accidents caused either by gross overdosage, producing symptoms of hypernoradrenalinaemia1 or more frequently by interacting with other drugs such as sympathomimetic amines2–5, amine precursors6–9, central nervous system depressants10–12 and also with foods containing tyramine, DOPA and other amines13.

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CURRY, A., MERCIER, M. Detection and Identification of Monoamine Oxidase Inhibitors in Biological Samples. Nature 228, 281–282 (1970). https://doi.org/10.1038/228281a0

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