Detection and Identification of Monoamine Oxidase Inhibitors in Biological Samples


THE monoamine oxidase (MAO) inhibitor drugs are now widely used in psychiatric practice for the management of various types of neurotic and psychotic depressions; unfortunately, these therapeutically valuable drugs are implicated in an increasing number of severe and some times fatal accidents caused either by gross overdosage, producing symptoms of hypernoradrenalinaemia1 or more frequently by interacting with other drugs such as sympathomimetic amines2–5, amine precursors6–9, central nervous system depressants10–12 and also with foods containing tyramine, DOPA and other amines13.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Sainz, A., Dis. Nerv. Syst., 20, 537 (1959).

  2. 2

    Brownlee, G., and Williams, G. W., Lancet, i, 669 (1963).

  3. 3

    Tonks, C. M., and Livingston, D., Lancet, i, 1323 (1963).

  4. 4

    Schrire, I., Brit. Med. J., 2, 748 (1963).

  5. 5

    Low-Beer, G. A., and Tidmarsh, D., Brit. Med. J., 2, 683 (1963).

  6. 6

    Pare, C. M. B., Lancet, ii, 527 (1963).

  7. 7

    Blomley, D. J., Lancet, ii, 1181 (1964).

  8. 8

    Hodge, J. V., Lancet, i, 764 (1965).

  9. 9

    Friend, D. G., Bell, W. R., and Kline, N. A., Clin. Pharmacol. Ther., 6, 363 (1965).

  10. 10

    Dillon, H., and Leopold, R. L., Amer. J. Psychiat., 121, 1012 (1965).

  11. 11

    Bethune, H. C., Burrell, R. H., Culpan, R. H., and Ogg, G. J., Amer. J. Psychiat., 121, 245 (1964).

  12. 12

    Churchill-Davidson, H. C., Brit. Med. J., 1, 520 (1965).

  13. 13

    Horwitz, D., Lovenberg, W., Engelman, K., and Sjoerdsma, A., J. Amer. Med. Assoc., 188, 1108 (1964).

  14. 14

    Lagnado, J. R., and Sourkes, T. L., Canad. J. Biochem. Physiol., 34, 1095 (1956).

  15. 15

    Glenner, G. G., Burtner, H. J., and Brown, G. W., J. Histochem. Cytochem., 5, 591 (1957).

  16. 16

    Weissbach, H., Redfield, B. G., Glenner, G. G., and Mitonia, C., J. Histochem. Cytochem., 5, 601 (1957).

  17. 17

    Hawkins, J., Biochem. J., 50, 577 (1952).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

CURRY, A., MERCIER, M. Detection and Identification of Monoamine Oxidase Inhibitors in Biological Samples. Nature 228, 281–282 (1970).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.