Abstract
There are at least six pharmacologically effective components of cannabis. Their effects on mice include a lowering of body temperature, catalepsy, analgesia and an extension of barbiturate sleeping time, with doses from 25 to 200 mg/kg.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mechoulam, R., and Gaoni, Y., Progress in the Chemistry of Organic Natural Products, 25, 175 (Springer, New York, 1967).
Korte, F., and Sieper, H., Annalen, 630, 71 (1960).
Miras, C. J., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).
Garattini, S., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).
Holtzman, D., Lovell, R. A., Jaffe, J. H., and Freedman, D. X., Science, 163, 1464 (1969).
Herrington, L. P., Amer. J. Physiol., 129, 123 (1940).
Loewe, S., J. Pharmac. Exp. Ther., 88, 154 (1946).
Siegmund, E., Cadmus, R., and Lu, G., Proc. Soc. Exp. Biol. Med., 95, 729 (1957).
Cortez, L., Chaud Sob, J., and Louzada, N. L., Third Internat. Pharmacol. Congr., Abstracts, 667 (1966).
Bicher, H. I., and Mechoulam, R., Arch. Int. Pharmacodyn., 172, 24 (1968).
Buxbaum, D., Sanders-Bush, E., and Efron, D. H., Fed. Proc., 28, 735 (1969).
Loewe, S., Arch. Exp. Path. Pharmak., 211, 175 (1950).
Persaud, T. V. N., and Ellingham, A. C., Lancet, ii, 406 (1968).
Geber, W. F., and Schramm, L. C., Arch. Int. Pharmacodyn., 177, 224 (1969).
Persaud, T. V. N., and Ellington, A. C., Lancet, 2, 1306 (1967).
Paton, W. D. M., Brit. J. Pharmacol., 12, 119 (1957).
Paton, W. D. M., and Vizi, E. S., Brit. J. Pharmacol., 35, 10 (1969).
Speden, R. N., Brit. J. Pharmacol., 25, 104 (1965).
Hindmarsh, I., Brit. J. Addiction, 64, 395 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILL, E., PATON, W. & PERTWEE, R. Preliminary Experiments on the Chemistry and Pharmacology of Cannabis. Nature 228, 134–136 (1970). https://doi.org/10.1038/228134a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/228134a0
This article is cited by
-
Biological activity of Cannabis compounds: a modern approach to the therapy of multiple diseases
Phytochemistry Reviews (2022)
-
Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes
Journal of Cannabis Research (2020)
-
Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders
CNS Drugs (2019)
-
Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice
Naunyn-Schmiedeberg's Archives of Pharmacology (2018)
-
Anticipatory nausea in animal models: a review of potential novel therapeutic treatments
Experimental Brain Research (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.