Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Preliminary Experiments on the Chemistry and Pharmacology of Cannabis

Abstract

There are at least six pharmacologically effective components of cannabis. Their effects on mice include a lowering of body temperature, catalepsy, analgesia and an extension of barbiturate sleeping time, with doses from 25 to 200 mg/kg.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mechoulam, R., and Gaoni, Y., Progress in the Chemistry of Organic Natural Products, 25, 175 (Springer, New York, 1967).

    Google Scholar 

  2. Korte, F., and Sieper, H., Annalen, 630, 71 (1960).

    Article  CAS  Google Scholar 

  3. Miras, C. J., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).

    Google Scholar 

  4. Garattini, S., in Hashish, Ciba Foundation Study Group No. 21 (Churchill, London, 1965).

    Google Scholar 

  5. Holtzman, D., Lovell, R. A., Jaffe, J. H., and Freedman, D. X., Science, 163, 1464 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Herrington, L. P., Amer. J. Physiol., 129, 123 (1940).

    CAS  Google Scholar 

  7. Loewe, S., J. Pharmac. Exp. Ther., 88, 154 (1946).

    CAS  Google Scholar 

  8. Siegmund, E., Cadmus, R., and Lu, G., Proc. Soc. Exp. Biol. Med., 95, 729 (1957).

    Article  CAS  Google Scholar 

  9. Cortez, L., Chaud Sob, J., and Louzada, N. L., Third Internat. Pharmacol. Congr., Abstracts, 667 (1966).

    Google Scholar 

  10. Bicher, H. I., and Mechoulam, R., Arch. Int. Pharmacodyn., 172, 24 (1968).

    CAS  PubMed  Google Scholar 

  11. Buxbaum, D., Sanders-Bush, E., and Efron, D. H., Fed. Proc., 28, 735 (1969).

    Google Scholar 

  12. Loewe, S., Arch. Exp. Path. Pharmak., 211, 175 (1950).

    Article  CAS  Google Scholar 

  13. Persaud, T. V. N., and Ellingham, A. C., Lancet, ii, 406 (1968).

    Article  Google Scholar 

  14. Geber, W. F., and Schramm, L. C., Arch. Int. Pharmacodyn., 177, 224 (1969).

    CAS  PubMed  Google Scholar 

  15. Persaud, T. V. N., and Ellington, A. C., Lancet, 2, 1306 (1967).

    Article  CAS  Google Scholar 

  16. Paton, W. D. M., Brit. J. Pharmacol., 12, 119 (1957).

    CAS  Google Scholar 

  17. Paton, W. D. M., and Vizi, E. S., Brit. J. Pharmacol., 35, 10 (1969).

    Article  CAS  Google Scholar 

  18. Speden, R. N., Brit. J. Pharmacol., 25, 104 (1965).

    CAS  PubMed  Google Scholar 

  19. Hindmarsh, I., Brit. J. Addiction, 64, 395 (1970).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GILL, E., PATON, W. & PERTWEE, R. Preliminary Experiments on the Chemistry and Pharmacology of Cannabis. Nature 228, 134–136 (1970). https://doi.org/10.1038/228134a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228134a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing