Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Morphological Changes in Chick Cerebellum induced by Poly I · Poly C

Nature volume 228, pages 1191–1192 (1970)Cite this article

Abstract

A COMPLEX of polyinosinic acid and polycytidylic acid (poly I · poly C) induces resistance to viral infections in mice1 and is an effective inducer of interferon in rabbits1,2 and mice3. This antiviral drug has been used in the treatment of herpetic keratoconjunctivitis in rabbits4, against viral tumours in mice5,6, and in clinical trials in patients with certain types of cancer7. Recent studies have indicated a high degree of toxicity for this synthetic double stranded RNA-like polymer8–11.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Absher, M., and Stinebring, W. R., Nature, 223, 715 (1969).

    Article  ADS  CAS  Google Scholar 

  3. Youngner, J. S., and Hollum, J. V., Virology, 35, 177 (1968).

    Article  CAS  Google Scholar 

  4. Park, J. H., and Baron, S., Science, 162, 811 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Levy, H. B., Law, L. W., and Rabson, A. S., Proc. Amer. Assoc. Cancer Res., 10, 49 (1969).

    Google Scholar 

  6. Sarma, P. S., Baron, S., Huebner, R. J., and Shiu, G., Nature, 224, 604 (1969).

    Article  ADS  CAS  Google Scholar 

  7. Levy, H. B., Antibiot. News, 6, 1 (1969).

    Google Scholar 

  8. Homan, E. R., Zendzian, R. P., and Adamson, R. H., Proc. Amer. Assoc. Cancer Res., 10, 40 (1969).

    Google Scholar 

  9. Lindsay, H. L., Trown, R. W., Brandt, J., and Forbes, M., Nature, 223, 717 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Adamson, R. H., and Fabro, S., Nature, 223, 718 (1969).

    Article  ADS  CAS  Google Scholar 

  11. Leonard, B. J., Eccleston, E., and Jones, D., Nature, 224, 1023 (1969).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Anatomy and Neurology and Psychiatry, Saint Louis University School of Medicine, St Louis, Missouri, 63104

    PAUL A. YOUNG, JOHN J. TAYLOR, MANG C. Yu & EDWARD EYERMAN

Authors
  1. PAUL A. YOUNG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JOHN J. TAYLOR
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. MANG C. Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. EDWARD EYERMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

YOUNG, P., TAYLOR, J., Yu, M. et al. Morphological Changes in Chick Cerebellum induced by Poly I · Poly C. Nature 228, 1191–1192 (1970). https://doi.org/10.1038/2281191a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2281191a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing