Abstract
THE antiviral activity of rifampin1–7 is based solely on studies in vitro; we have therefore investigated the action of this drug in experimental animals against a series of standardized subclinical infections8 produced by both DNA and RNA viruses. Drug efficacy was also considered against the lethal infections produced in mice after the intracerebral inoculation of vaccinia and herpes simplex viruses. Of the eight infections studied, only the H-1 virus infection in hamsters showed any evidence of alteration resulting from treatment with maximally tolerated doses of rifampin8 (Table 1). We here report our positive findings in vivo.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).
Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).
McAuslan, B. R., Biochem. Biophys. Res. Commun., 37, 289 (1969).
Moss, B., Katz, E., and Rosenblum, E. N., Biochem. Biophys. Res. Commun., 36, 858 (1969).
Moss, B., Rosenblum, E. N., Katz, E., and Grimley, P. M., Nature, 224, 1280 (1969).
Ben-Ishai, Z., Heller, E., Goldblum, N., and Becker, Y., Nature, 224, 29 (1969).
Diggelmann, H., and Weissmann, C., Nature, 224, 1277 (1969).
Engle, C. G., Frankel, J. W., and Gelzer, J., Ann. NY Acad. Sci. (in the press).
Toolan, H. W., Intern. Rev. Exp. Pathol., 6, 135 (1968).
Toolan, H. W., Proc. Soc. Exp. Biol. Med., 124, 144 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ENGLE, C., LASINSKI, E. & GELZER, J. Rifampin Inhibition of H-1 Virus Infection in Hamsters. Nature 228, 1190–1191 (1970). https://doi.org/10.1038/2281190a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2281190a0
This article is cited by
-
Effect of Rifampicin on the Development of Tumours induced by Adenovirus in Male Hamsters
Nature New Biology (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
