Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

Abstract

Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Temin, H. M., Nat. Cancer Inst. Monog., 17, 557 (1964).

    Google Scholar 

  2. Cole, R. K., and Furth, J., Cancer Res., 1, 957 (1941).

    Google Scholar 

  3. Temin, H. M., Cancer Res., 28, 1835 (1968).

    CAS  PubMed  Google Scholar 

  4. Temin, H. M., Proc. US Nat. Acad. Sci., 52, 323 (1964).

    Article  ADS  CAS  Google Scholar 

  5. Baluda, M. B., and Nayak, D. P., in Biology of Large RNA Viruses (edit. by Barry, R., and Mahy, B.) (Academic Press, New York, 1970).

    Google Scholar 

  6. Baltimore, D., Nature, 226, 1209 (1970).

    Article  ADS  CAS  Google Scholar 

  7. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).

    Article  ADS  CAS  Google Scholar 

  8. Graff, S., Moore, D. H., Stanley, W. H., Randall, H. T., and Haagensen, C. D., Cancer, 2, 755 (1949).

    Article  CAS  Google Scholar 

  9. Ricard, C. G., Post, J. E., Noronha, F., and Barr, L. M., J. Nat. Cancer Inst., 42, 987 (1969).

    Google Scholar 

  10. Carnegie, J. W., Deeney, A. O'C., Olson, K. C., and Beaudreau, G. S., Biochim. Biophys. Acta, 190, 274 (1969).

    Article  CAS  Google Scholar 

  11. Josse, J. A., Kaiser, A. D., and Kornberg, A., J. Biol. Chem., 236, 864 (1961).

    CAS  Google Scholar 

  12. Hall, B. D., and Spiegelman, S., Proc. US Nat. Acad. Sci., 47, 114 (1961).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

SPIEGELMAN, S., BURNY, A., DAS, M. et al. Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses. Nature 227, 563–567 (1970). https://doi.org/10.1038/227563a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/227563a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing