Abstract
Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Temin, H. M., Nat. Cancer Inst. Monog., 17, 557 (1964).
Cole, R. K., and Furth, J., Cancer Res., 1, 957 (1941).
Temin, H. M., Cancer Res., 28, 1835 (1968).
Temin, H. M., Proc. US Nat. Acad. Sci., 52, 323 (1964).
Baluda, M. B., and Nayak, D. P., in Biology of Large RNA Viruses (edit. by Barry, R., and Mahy, B.) (Academic Press, New York, 1970).
Baltimore, D., Nature, 226, 1209 (1970).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Graff, S., Moore, D. H., Stanley, W. H., Randall, H. T., and Haagensen, C. D., Cancer, 2, 755 (1949).
Ricard, C. G., Post, J. E., Noronha, F., and Barr, L. M., J. Nat. Cancer Inst., 42, 987 (1969).
Carnegie, J. W., Deeney, A. O'C., Olson, K. C., and Beaudreau, G. S., Biochim. Biophys. Acta, 190, 274 (1969).
Josse, J. A., Kaiser, A. D., and Kornberg, A., J. Biol. Chem., 236, 864 (1961).
Hall, B. D., and Spiegelman, S., Proc. US Nat. Acad. Sci., 47, 114 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SPIEGELMAN, S., BURNY, A., DAS, M. et al. Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses. Nature 227, 563–567 (1970). https://doi.org/10.1038/227563a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227563a0
This article is cited by
-
Experimental Series and the Justification of Temin’s DNA Provirus Hypothesis
Synthese (2007)
-
Knowledge and structures of scientific growth measurement of a cancer problem domain
Scientometrics (1979)
-
Particles from mouse melanoma B16 containing reverse transcriptase and 70S RNA related to human melanoma cytoplasmic RNA
Archives of Dermatological Research (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.