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Mechanism of Chromosome Pairing during Meiosis

Abstract

Electron microscopy with whole mount preparations has revealed that the synaptonemal complex merely pulls two homologous chromosomes together. Intimate molecular pairing is another matter—probably brought about by connexions between short stretches of single stranded DNA.

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References

  1. Moses, M. J., Ann. Rev. Genet., 2, 363 (1968).

    Article  Google Scholar 

  2. Moens, P. B., Chromosoma, 23, 418 (1968).

    Article  Google Scholar 

  3. Schin, K. S., Chromosoma, 16, 436 (1966).

    Article  Google Scholar 

  4. Roth, T. F., Protoplasma, 61, 346 (1966).

    Article  Google Scholar 

  5. Gassner, G., Chromosoma, 26, 22 (1969).

    Article  Google Scholar 

  6. Comings, D. E., and Okada, T. A., Chromosoma (in the press).

  7. Nebel, B. R., and Coulon, E. M., Chromosoma, 13, 292 (1962).

    Article  CAS  PubMed  Google Scholar 

  8. Brinkley, B. R., and Bryan, J. H. D., J. Cell Biol., 23, 14A (1964).

    Google Scholar 

  9. Coleman, J. R., and Moses, M. J., J. Cell Biol., 23, 63 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Moens, P. B., Chromosoma, 28, 1 (1969).

    Article  CAS  PubMed  Google Scholar 

  11. Thomas, C. A., in Prog. Nucleic Acid Res. and Mol. Biol. (edit. by Davidson, J. K, and Cohn, W. E.), 315 (Academic Press, New York, 1966).

    Google Scholar 

  12. Holliday, R., in Replication and Recombination of Genetic Material (edit. by Peacock, W. J., and Brock, R. D.), 157 (Australian Academy of Science, Canberra, 1968).

    Google Scholar 

  13. Whitehouse, H. L. K., Nature, 199, 1034 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Whitehouse, H. L. K., Nature, 211, 709 (1966).

    Article  ADS  Google Scholar 

  15. Darlington, C. D., J. Genet., 31, 185 (1935).

    Article  Google Scholar 

  16. Comings, D. E., Amer. J. Human Genet., 20, 440 (1968).

    CAS  Google Scholar 

  17. Stack, S. M., and Brown, W. V., Nature, 222, 1275 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Huettner, A. F., J. Morphol. Physiol., 39, 249 (1924).

    Article  Google Scholar 

  19. Franchi, L. L., and Mandl, A. M., Proc. Roy. Soc., B, 157, 99 (1962).

    Article  ADS  Google Scholar 

  20. John, B., and Lewis, K. R., in Protoplasmatologia, 67 (Springer-Verlag, Wien, 1965).

    Google Scholar 

  21. Rhoades, M. M., in Replication and Recombination of Genetic Material (edit. by Peacock, W. J., and Brock, R. D.), 229 (Australian Academy of Science, Canberra, 1968).

    Google Scholar 

  22. Menzel, M. Y., and Price, J. M., Amer. J. Bot., 53, 1079 (1966).

    Article  Google Scholar 

  23. Tabata, M., Cytologia, 28, 278 (1963).

    Article  Google Scholar 

  24. Hoyer, B. H., McCarthy, B. J., and Bolton, E. T., Science, 144, 959 (1964).

    Article  ADS  CAS  Google Scholar 

  25. Jacob, F., and Wollman, E. L., Ann. Inst. Pasteur, 88, 724 (1955).

    CAS  Google Scholar 

  26. Howard-Flanders, P., Rupp, W. D., and Wilkins, B. M., in Replication and Recombination of Genetic Material (edit. by Peacock, W. J., and Brock, R. D.), 142 (Australian Academy of Science, Canberra, 1969).

    Google Scholar 

  27. Pritchard, R. H., in Microbial Genetics, Tenth Symp. Soc. Gen. Microbiol., 155 (Cambridge University Press, 1960).

    Google Scholar 

  28. Lindsey, D. L., Sandler, L., Nicoletti, B., and Trippa, G., in Replication and Recombination of Genetic Material (edit. by Peacock, W. J., and Brock, R. D.), 253 (Australian Academy of Science, Canberra, 1968).

    Google Scholar 

  29. Green, M. M., Genetica, 33, 154 (1962).

    Article  CAS  PubMed  Google Scholar 

  30. Roberts, P. A., Genetics, 52, 1017 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Judd, B. H., Genetics, 52, 1229 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Peacock, W. J., in Replication and Recombination of Genetic Material (edit. by Peacock, W. J., and Brock, R. D.), 242 (Australian Academy of Science, Canberra, 1968).

    Google Scholar 

  33. Green, M. M., Mol. Gen. Genet., 103, 209 (1968).

    Article  CAS  PubMed  Google Scholar 

  34. Laughnan, J. R., Genetics, 46, 1347 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. King, R. C., Int. Rev. Cytol., 28, 125 (1970).

    Article  CAS  PubMed  Google Scholar 

  36. Hotta, Y., Ito, M., and Stern, H., Proc. US Nat. Acad. Sci., 56, 1184 (1966).

    Article  ADS  CAS  Google Scholar 

  37. Taylor, J. H., in Molecular Genetics (edit. by Taylor, J. H.), 2 (Academic Press, New York, 1967).

    Google Scholar 

  38. Whitehouse, H. L. K., Nature, 215, 1352 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Stern, C., Genetics, 21, 625 (1936).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Ronen, A., Genetics, 50, 649 (1964).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Smith, P. A., and King, R. C., Genetics, 60, 335 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Portecorvo, G., Trends in Genetic Analysis (Oxford University Press, Oxford, 1959).

    Google Scholar 

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COMINGS, D., OKADA, T. Mechanism of Chromosome Pairing during Meiosis. Nature 227, 451–456 (1970). https://doi.org/10.1038/227451a0

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