Abstract
LYMPHOCYTE transformation induced by phytohaemagglutinin (PHA) or other antigens is inhibited when the cells are cultured in the presence of arginine-using Mycoplasma species or in arginine-free medium1–5. Although essential to the activation of small lymphocytes by PHA, arginine is thought not to be essential for transformed cells4. The effect of arginine on human lymphoblastoid cell lines has not been formally reported, but is said to affect the production of EB virus (W. Henle and R. T. S., unpublished work). Although arginine is clearly essential for the chain of events leading to morphological transformation and mitotic activity of lymphocytes in vitro3,4, the exact role of the amino-acid is obscure. Arginine might be essential for the synthesis or stability of the surface receptors for lymphocyte activating substances, or for the synthesis of substances involved in the biochemical changes which precede or accompany DNA synthesis and mitotic activity of transformed cells.
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OSUNKOYA, B., ADLER, W. & SMITH, R. Effect of Arginine Deficiency on Synthesis of DNA and Immunoglobulin Receptor of Burkitt Lymphoma Cells. Nature 227, 398–399 (1970). https://doi.org/10.1038/227398a0
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DOI: https://doi.org/10.1038/227398a0
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