Abstract
THE discovery of sex-linked anaemia in the descendants of an irradiated mouse was followed by further evidence and the suggestion2 that there was a hereditary defect in intestinal iron absorption in these animals. Our studies on everted gut sacs in vitro provide the first direct evidence of a selective genetic defect in the second or serosal transfer step3 of the active transport mechanism for iron in the duodenum of the sex-linked anaemic (sla) mouse.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Falconer, D. S., and Isaacson, J. H., Genet. Res. Camb., 3, 248 (1962).
Pinkerton, P. H., and Bannerman, R. M., Nature, 216, 482 (1967).
Manis, J. G., and Schachter, D., Amer. J. Physiol., 203, 73 (1962).
Biology of the Laboratory Mouse (edit. by Green, E. L.), second ed., 352 (McGraw-Hill, New York).
Manis, J. G., and Schachter, D., Amer. J. Physiol., 203, 81 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MANIS, J. Active Transport of Iron by Intestine: Selective Genetic Defect in the Mouse. Nature 227, 385–386 (1970). https://doi.org/10.1038/227385a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227385a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.