Abstract
CHANGES in the activity of enzymes which destroy angiotensin may be concerned in the development of hypertension, but many relevant studies have involved tissue homogenates1–7 which may not reflect accurately the capacity of intact organs to remove circulating angiotensin. Intracellular enzymes, that normally have limited or no access to perfusing blood, are released when tissue extracts are prepared. Others8–11, however, recognizing this problem, investigated angiotensin inactivation by perfused organs in vivo, and demonstrated the dominant role of organ vascular beds in the inactivation of angiotensin in rats and dogs and the relative unimportance of circulating angiotensinases. A tentative explanation is that tissue enzymes are involved rather than storage of angiotensin at receptor sites (results of W. P. L., J. G. L. and J. W. Ryan, unpublished).
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LEARY, W., LEDINGHAM, J. Inactivation of Angiotensin II Analogues by Isolated Perfused Rat Liver and Kidney. Nature 227, 178–179 (1970). https://doi.org/10.1038/227178a0
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DOI: https://doi.org/10.1038/227178a0
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