Abstract
THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years1–3, and its susceptibility to viruses infective for man1,4, explain the value of such material for the isolation of viruses and in the development of vaccines5–8. We have developed another strain of cells, also derived from foetal lung tissue, taken from a 14-week male foetus removed for psychiatric reasons from a 27 year old woman with a genetically normal family history and no sign of neoplastic disease both at abortion and for at least three years afterwards. The criteria used for characterizing the cells are those recommended internationally2,9.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hayflick, L., and Moorhead, P. S., Exp. Cell. Res., 25, 585 (1961).
Minutes Fifth Meeting Committee on Cell Cultures, Permanent Section on Microbiological Standardization, 40 (Intern. Assoc. Microbiol. Socs., 1968).
Trlifajova, J., and Strizova, V., J. Hyg. Epidemiol. Microbiol. Immunol., 10, 510 (1966).
Herrman, jun., E. C., Amer. J. Epidemiol., 85, 200 (1967).
Hayflick, L., Plotkin, S. A., Norton, T. W., and Koprowski, H., Amer. J. Hyg., 75, 240 (1962).
Ikie, D., Prog. Immunobiol., 2, 305 (1965).
Chanock, R. M., Ludwig, W., Huebner, R. J., Cate, T. R., and Liang-Wei Chu, J. Amer. Med. Assoc., 195, 445 (1966).
Plotkin, S. A., Farquhar, J., Katz, M., and Ingalls, T., Amer. J. Epidemiol., 86, 468 (1967).
Proc. Symp. on Characterization and Uses of Human Diploid Cell Strains, Opatija, Yugoslavia, 1963, 709).
McCarthy, K., Taylor-Robinson, C. H., and Pillinger, S. E., Lancet, ii, 593 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JACOBS, J., JONES, C. & BAILLE, J. Characteristics of a Human Diploid Cell Designated MRC-5. Nature 227, 168–170 (1970). https://doi.org/10.1038/227168a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/227168a0
This article is cited by
-
LRRC superfamily expression in stromal cells predicts the clinical prognosis and platinum resistance of ovarian cancer
BMC Medical Genomics (2023)
-
Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling
Journal of Materials Science: Materials in Medicine (2023)
-
E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1
Scientific Reports (2022)
-
Convenient route to benzo[1,2,3]selenadiazole–isoxazole hybrids and evaluation of their in vitro cytotoxicity
Chemical Papers (2022)
-
Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model
Human Cell (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.