Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Characteristics of a Human Diploid Cell Designated MRC-5

Abstract

THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years1–3, and its susceptibility to viruses infective for man1,4, explain the value of such material for the isolation of viruses and in the development of vaccines5–8. We have developed another strain of cells, also derived from foetal lung tissue, taken from a 14-week male foetus removed for psychiatric reasons from a 27 year old woman with a genetically normal family history and no sign of neoplastic disease both at abortion and for at least three years afterwards. The criteria used for characterizing the cells are those recommended internationally2,9.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hayflick, L., and Moorhead, P. S., Exp. Cell. Res., 25, 585 (1961).

    Article  CAS  Google Scholar 

  2. Minutes Fifth Meeting Committee on Cell Cultures, Permanent Section on Microbiological Standardization, 40 (Intern. Assoc. Microbiol. Socs., 1968).

  3. Trlifajova, J., and Strizova, V., J. Hyg. Epidemiol. Microbiol. Immunol., 10, 510 (1966).

    CAS  PubMed  Google Scholar 

  4. Herrman, jun., E. C., Amer. J. Epidemiol., 85, 200 (1967).

    Article  Google Scholar 

  5. Hayflick, L., Plotkin, S. A., Norton, T. W., and Koprowski, H., Amer. J. Hyg., 75, 240 (1962).

    CAS  PubMed  Google Scholar 

  6. Ikie, D., Prog. Immunobiol., 2, 305 (1965).

    Google Scholar 

  7. Chanock, R. M., Ludwig, W., Huebner, R. J., Cate, T. R., and Liang-Wei Chu, J. Amer. Med. Assoc., 195, 445 (1966).

    Article  CAS  Google Scholar 

  8. Plotkin, S. A., Farquhar, J., Katz, M., and Ingalls, T., Amer. J. Epidemiol., 86, 468 (1967).

    Article  CAS  Google Scholar 

  9. Proc. Symp. on Characterization and Uses of Human Diploid Cell Strains, Opatija, Yugoslavia, 1963, 709).

  10. McCarthy, K., Taylor-Robinson, C. H., and Pillinger, S. E., Lancet, ii, 593 (1963).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JACOBS, J., JONES, C. & BAILLE, J. Characteristics of a Human Diploid Cell Designated MRC-5. Nature 227, 168–170 (1970). https://doi.org/10.1038/227168a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/227168a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing