Inhibition of Oncogenicity of Murine Sarcoma Virus (Harvey) in Mice by Interferon

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Abstract

HOMOLOGOUS interferon preparations have been shown to inhibit the oncogenicity of polyoma virus1 and the evolution of several murine leukaemias2–5. Although treatment of mice with polycytidylic–polyinosinic acid, an inducer of endogenous interferon, was associated with inhibition of the oncogenicity of murine sarcoma virus, Moloney strain (MSV–M)6,7 exogenous interferon was reported to be ineffective in newborn BALB/c mice inoculated with this virus7,8. By contrast, we report the efficacy of exogenous interferon preparations in the treatment of adult BALB/c mice inoculated with the Harvey strain of murine sarcoma virus (MSV–H).

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BERMAN, L. Inhibition of Oncogenicity of Murine Sarcoma Virus (Harvey) in Mice by Interferon. Nature 227, 1349–1350 (1970) doi:10.1038/2271349a0

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