Growth of Porcine Transmissible Gastroenteritis (TGE) Virus in Organ Cultures of Pig Tissue

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IT has been shown recently that it is possible to grow viruses in organ cultures of human (ref. 1 and personal communication from D. Egglestone) and mouse1 intestinal tract. It seemed to us that these cultures might support the growth of viruses of the alimentary tract of man which are postulated to cause diseases such as acute gastroenteritis and winter vomiting disease. Transmissible gastroenteritis (TGE) of pigs resembles these diseases in many ways2, and the virus can be detected and precisely titrated in tissue cultures3,4; it therefore seemed to be a suitable model on which to test the hypothesis that a gastroenteritis virus might grow in organ cultures of the gut.

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  1. 1

    Rubenstein, D., and Tyrrell, D. A. J., Brit. J. Exp. Path., 51, 210 (1970).

  2. 2

    Haelterman, E. O., and Hooper, B. E., Gastroenterology, 53, 109 (1967).

  3. 3

    Cartwright, S. F., Harris, H. M., Blandford, T. B., Fincham, I., and Gitter, M., J. Comp. Path., 75, 387 (1965).

  4. 4

    Witte, K. H., and Easterday, B. C., Arch. Ges. Virusforsch., 20, 327 (1967).

  5. 5

    Hooper, B. E., and Haelterman, E. O., Amer. J. Vet. Res., 27, 286 (1966).

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RUBENSTEIN, D., TYRRELL, D., DERBYSHIRE, J. et al. Growth of Porcine Transmissible Gastroenteritis (TGE) Virus in Organ Cultures of Pig Tissue. Nature 227, 1348–1349 (1970) doi:10.1038/2271348a0

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