Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

T4 Bacteriophage Gene 32: A Structural Protein in the Replication and Recombination of DNA

Abstract

A new type of protein essential for DNA replication and genetic recombination has been isolated from T4 bacteriophage-infected cells of E. coli. This protein binds cooperatively to single-stranded DNA, and it catalyses DNA denaturation and renaturation in physiological conditions in vitro.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Meselson, M., in Heritage from Mendel (edit. by Brink, R. A.), (Univ. Wisconsin Press, 1967).

    Google Scholar 

  2. Tomizawa, J., J. Cell. Physiol., 70, Suppl. 1, 201 (1967).

    CAS  Article  Google Scholar 

  3. Shahn, E., and Kozinski, A., Virology, 30, 455 (1966).

    CAS  Article  Google Scholar 

  4. Hershey, A. D., and Chase, M., Cold Spring Harbor Symp. Quant. Biol., 16, 471 (1951).

    CAS  Article  Google Scholar 

  5. Holliday, R., Genet. Res., 5, 282 (1964).

    Article  Google Scholar 

  6. Whitehouse, H. L. K., Nature, 199, 1034 (1963).

    ADS  CAS  Article  Google Scholar 

  7. Thomas, C. A., Prog. Nucleic Acid Res. Mol. Biol., 5, 315 (1966).

    Article  Google Scholar 

  8. Marmur, J., and Doty, P., J. Mol. Biol., 5, 109 (1962).

    CAS  Article  Google Scholar 

  9. Wang, J. C., and Davidson, N., Cold Spring Harbor Symp. Quant. Biol., 33, 409 (1968).

    CAS  Article  Google Scholar 

  10. Doermann, A. H., and Parma, D. H., J. Cell. Physiol., 70, Suppl. 1, 147 (1967).

    Article  Google Scholar 

  11. Signer, E., Echols, H., Weil, J., Radding, C. M., Shulman, M., Moore, L., and Manly, K., Cold Spring Harbor Symp. Quant. Biol., 33, 711 (1968).

    CAS  Article  Google Scholar 

  12. Buttin, G., and Wright, M., Cold Spring Harbor Symp. Quant. Biol., 33, 259 (1968).

    CAS  Article  Google Scholar 

  13. Doty, P., Boedtker, H., Fresco, J. R., Haselkorn, R., and Litt, M., Proc. US Nat. Acad. Sci., 45, 482 (1959).

    ADS  CAS  Article  Google Scholar 

  14. Doty, P., Marmur, J., Eigner, J., and Schildkraut, C., Proc. US Nat. Acad. Sci., 46, 461 (1960).

    ADS  CAS  Article  Google Scholar 

  15. Studier, F. W., J. Mol. Biol., 41, 199 (1969).

    CAS  Article  Google Scholar 

  16. Tomizawa, J., Anraku, N., and Iwama, Y., J. Mol. Biol., 21, 247 (1966).

    CAS  Article  Google Scholar 

  17. Epstein, R. H., Bolle, A., Steinberg, C. M., Kellenberger, E., Boy de la Tour, E., Chevalley, R., Edgar, R. S., Susman, M., Denhardt, G. H., and Lielausis, A., Cold Spring Harbor Symp. Quant. Biol., 28, 375 (1963).

    CAS  Article  Google Scholar 

  18. Kozinski, A., and Felgenhauer, Z. Z., J. Virol., 1, 1193 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Alberts, B. M., Amodio, F. J., Jenkins, M., Gutmann, E. D., and Ferris, F. L., Cold Spring Harbor Symp. Quant. Biol., 33, 289 (1968).

    CAS  Article  Google Scholar 

  20. Alberts, B. M., Fed. Proc., 29, 1154 (1970).

    CAS  PubMed  Google Scholar 

  21. Snustad, D. P., Virology, 35, 550 (1968).

    CAS  Article  Google Scholar 

  22. Shapiro, A. L., Vinuela, E., and Maizel, J. V., Biochem. Biophys. Res. Commun., 28, 815 (1967).

    CAS  Article  Google Scholar 

  23. Marvin, D. A., and Hohn, B., Bact. Rev., 33, 172 (1969).

    CAS  Google Scholar 

  24. Knippers, R., and Hoffmann-Berling, H., J. Mol. Biol., 21, 293 (1966).

    CAS  Article  Google Scholar 

  25. Akinrimisi, E. O., Bonner, J., and Tso, P. O. P., J. Mol. Biol., 11, 128 (1965).

    CAS  Article  Google Scholar 

  26. Mahler, H. R., and Mehrotra, B. D., Biochim. Biophys. Acta, 68, 211 (1963).

    CAS  Article  Google Scholar 

  27. Felsenfeld, G., Sandeen, G., and von Hippel, P. H., Proc. US Nat. Acad. Sci., 50, 644 (1963).

    ADS  CAS  Article  Google Scholar 

  28. Scheffler, I. E., Elson, E. L., and Baldwin, R. L., . J. Mol. Biol., 48, 145 (1970).

    CAS  Article  Google Scholar 

  29. Studier, F. W., J. Mol. Biol., 11, 373 (1965).

    CAS  Article  Google Scholar 

  30. Wetmur, J. G., and Davidson, N., J. Mol. Biol., 31, 349 (1968).

    CAS  Article  Google Scholar 

  31. Kozinski, A. W., Kozinski, P. B., and James, R., J. Virol., 1, 758 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Goulian, M., Lucas, Z. J., and Kornberg, A., J. Biol. Chem., 243, 627 (1968).

    CAS  PubMed  Google Scholar 

  33. Werner, R., Cold Spring Harbor Symp. Quant. Biol., 33, 501 (1968).

    CAS  Article  Google Scholar 

  34. Mosig, G., and Werner, R., Proc. US Nat. Acad. Sci., 64, 747 (1969).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ALBERTS, B., FREY, L. T4 Bacteriophage Gene 32: A Structural Protein in the Replication and Recombination of DNA. Nature 227, 1313–1318 (1970). https://doi.org/10.1038/2271313a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2271313a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing