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Effect of Fatty Acids on Contractility and Rhythm of the Heart

Nature volume 227, pages 1055–1056 (1970)Cite this article

Abstract

SINCE the finding in 1961 that free fatty acids inhibit the myocardial oxygenation of glucose1, increasing emphasis has been placed on the role of free fatty acids as myocardial fuel2. It is now known that free fatty acids inhibit glucose metabolism at several sites3. In studies on the human heart in situ free fatty acids are the dominant fuel in the fasting state4. It has therefore been suggested that free fatty acids are of major importance as a source of myocardial energy.

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References

  1. Shipp, J. C., Opie, L. H., and Challoner, D., Nature, 189, 1018 (1961).

    Article  ADS  CAS  Google Scholar 

  2. Evans, J. R., Canad. J. Biochem., 42, 955 (1964).

    Article  CAS  Google Scholar 

  3. Randle, P. J., Ann. Rev. Physiol., 25, 291 (1963).

    Article  CAS  Google Scholar 

  4. Opie, L. H., Amer. Heart J., 77, 100 (1969).

    Article  CAS  Google Scholar 

  5. Oliver, M. F., Kurien, V. A., and Greenwood, T. W., Lancet, i, 710 (1968).

  6. Gupta, D. K., Young, R., Jewitt, D. E., Hartog, M., and Opie, L. H., Lancet, ii, 1209 (1969).

  7. Kurien, V. A., Yates, P. A., and Oliver, M. F., Lancet, ii, 185 (1969).

  8. Opie, L. H., J. Physiol., 180, 529 (1965).

    Article  CAS  Google Scholar 

  9. Opie, L. H., Amer. J. Physiol., 209, 1075 (1965).

    CAS  PubMed  Google Scholar 

  10. Randle, P. J., Newsholme, E. A., and Garland, P. B., Biochem. J., 93, 652 (1964).

    Article  CAS  Google Scholar 

  11. Garland, P. B., Newsholme, E. A., and Randle, P. J., Biochem. J., 93, 665 (1964).

    Article  CAS  Google Scholar 

  12. Opie, L. H., Shipp, J. C., and Evans, J. R., Amer. J. Physiol., 205, 1203 (1963).

    CAS  PubMed  Google Scholar 

  13. Falcone, A. B., and Rose, L. M., Biochim. Biophys. Acta, 105, 233 (1965).

    Article  CAS  Google Scholar 

  14. Siess, M., Müller, K., and Peter, U., Arzneim.-Forsch., 18, 1245 (1968).

    CAS  Google Scholar 

  15. Owen, P., Thomas, M., and Opie, L. H., Lancet, i, 1187 (1969).

  16. Henderson, A. H., Craig, R. J., Sonnenblick, E. H., and Gorlin, R., Cardiovasc. Res. (in the press, 1970).

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Authors and Affiliations

  1. MRC Cardiovascular Research Unit, Department of Medicine, Hammersmith Hospital, London, W12

    LIONEL H. OPIE

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  1. LIONEL H. OPIE
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OPIE, L. Effect of Fatty Acids on Contractility and Rhythm of the Heart. Nature 227, 1055–1056 (1970). https://doi.org/10.1038/2271055a0

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