Biological Sciences: Molecular Structure of 1-Methyl-4-thiouracil.9-methyladenine: Unusual Base Pair in tRNA

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Abstract

4-THIOURIDINE is a constituent of the tRNA of Escherichia coli1–3. It is located in a position where, according to the cloverleaf model, specific base pairing by hydrogen bonding is assumed not to occur. X-ray crystallographic4 and spectral analyses5 of the monomer and polymer nucleoside have been performed and 4-thiouridine is the first pyrimidine nucleoside that has been shown to exist in a syn conformation in the crystalline state. We now report studies on the molecular structure of the l-methyl-4-thiouracil.9-methyladenine complex.

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SAENGER, W., SUCK, D. Biological Sciences: Molecular Structure of 1-Methyl-4-thiouracil.9-methyladenine: Unusual Base Pair in tRNA. Nature 227, 1046–1047 (1970) doi:10.1038/2271046a0

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