Abstract
METACHROMATIC leucodystrophy (MLD) is a progressive neurodegenerative disorder inherited in an autosomal recessive fashion and characterized by the deposition of cerebroside sulphate in brain, peripheral nerves and visceral organs1–4. The storage of cerebroside sulphate is due to a deficiency of cerebroside sulphatase or arylsulphatase A5–7, which also acts on synthetic substrates.
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LEROY, J., DUMON, J. & RADERMECKER, J. Deficiency of Arylsulphatase A in Leucocytes and Skin Fibroblasts in Juvenile Metachromatic Leucodystrophy. Nature 226, 553–554 (1970). https://doi.org/10.1038/226553a0
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DOI: https://doi.org/10.1038/226553a0
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