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Daily Rhythms in Content and Utilization of Tyrosine in the Whole Mouse

Abstract

HEPATIC tyrosine transaminase activity in untreated rats1 or mice2 given free access to dietary protein3 and exposed to alternate periods of light and darkness4 undergoes four-fold variations during each 24 h period. Much of the amino-acid intake is metabolized by deamination5 and we have sought to determine whether the rate of transformation of injected tyrosine in the mouse varies with time of day.

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References

  1. Wurtman, R. J., and Axelrod, J., Proc. US Nat. Acad. Sci., 57, 1594 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Rose, C. M., Chou, C., Zigmond, M. J., and Wurtman, R. J., Fed. Proc., 28, 690 (1969).

    Google Scholar 

  3. Wurtman, R. J., Shoemaker, W. J., and Larin, F., Proc. US Nat. Acad. Sci., 59, 800 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Zigmond, M. J., Shoemaker, W. J., Larin, F., and Wurtman, R. J., J. Nutrit., 98, 71 (1969).

    CAS  PubMed  Google Scholar 

  5. Elwyn, D. H., in Mammalian Protein Metabolism (edit. by Munro, H. M.), 4 (Academic press, New York, in the Press).

  6. Waalkes, T. P., and Udenfriend, S., J. Lab. Clin. Med., 50, 733 (1957).

    CAS  PubMed  Google Scholar 

  7. Wurtman, R. J., in Mammalian Protein Metabolism (edit. by Munro, H. N.), 4 (Academic Press, New York, in the press).

  8. Coburn, S. P., Seidenberg, M., and Fuller, R. W., Proc. Soc. Exp. Biol. Med., 129, 338 (1968).

    Article  CAS  PubMed  Google Scholar 

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ROSE, C., WURTMAN, R. Daily Rhythms in Content and Utilization of Tyrosine in the Whole Mouse. Nature 226, 454–455 (1970). https://doi.org/10.1038/226454a0

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