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A Type of Contraction Hypothesis applicable to all Muscles

Nature volume 226, pages 417–420 (1970)Cite this article

Abstract

Electrostatic repulsion between filaments could play a key part in the contractile process, provided that constant lattice volume is maintained by viscous and other forces. An electrostatic–hydraulic mechanism could function with only actin in a filamentous form.

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References

  1. Huxley, H. E., and Hanson, J., Nature, 173, 973 (1954).

    Article  ADS  CAS  Google Scholar 

  2. Huxley, A. F., and Niedergerke, R., Nature, 173, 971 (1954).

    Article  ADS  CAS  Google Scholar 

  3. Huxley, H. E., in Muscle (edit. by Paul et al.) (Pergamon, London, 1964).

    Google Scholar 

  4. Huxley, A. F., Prog. Biophys. Biophys. Chem., 7, 225 (1957).

    Article  Google Scholar 

  5. Davies, R. E., Nature, 199, 1068 (1963).

    Article  ADS  CAS  Google Scholar 

  6. Huxley, H. E., Science, 164, 1356 (1969).

    Article  ADS  CAS  Google Scholar 

  7. Lowy, J., and Hanson, J., Physiol. Rev., 42, Suppl. 5, 34 (1962).

    Google Scholar 

  8. Hanson, J., and Lowy, J., Proc. Roy. Soc., B. 154, 173 (1961).

    Article  ADS  Google Scholar 

  9. Lowy, J., Hanson, J., Elliott, G. F., and McDonough, M. W., Ciba Foundation Symposium on Principles of Biomolecular Organization, 229 (Churchill, London, 1966).

    Google Scholar 

  10. Twarog, B. M., J. Gen. Physiol., 50, 157 (1967).

    Article  CAS  Google Scholar 

  11. Ruegg, J. C., Symp. Soc. Exp. Biol., 22, 45 (1968).

    CAS  PubMed  Google Scholar 

  12. Lowy, J., and Vibert, P. J., Nature, 215, 1254 (1967).

    Article  ADS  CAS  Google Scholar 

  13. Vibert, P. J., thesis, Univ. of London (1969).

  14. Hanson, J., and Lowy, J., Biochemistry of Muscle Contraction, 400 (edit. by J. Gergely) (Churchill, London, 1964).

    Google Scholar 

  15. Kendrick-Jones, J., Cohen, C., and Szent-Györgyi, A. G., Biophys. J., 9, A–94 (1969).

    Google Scholar 

  16. Kelly, R. E., and Rice, R. V., J. Cell. Biol., 37, 105 (1968).

    Article  CAS  Google Scholar 

  17. Nomura, Y., J. Cell. Biol., 39, 741 (1968).

    Article  Google Scholar 

  18. Pease, D. C., J. Ultrastr. Res., 23, 280 (1968).

    Article  Google Scholar 

  19. Kelly, R. E., and Rice, R. V., J. Cell Biol., 42, 683 (1969).

    Article  CAS  Google Scholar 

  20. Hanson, J., and Lowy, J., Proc. Roy. Soc., B, 160, 523 (1964).

    Article  ADS  Google Scholar 

  21. Shoenberg, C. F., Nature, 206, 526 (1965).

    Article  ADS  CAS  Google Scholar 

  22. Shoenberg, C. F., Tissue and Cell, 1, 83 (1969).

    Article  CAS  Google Scholar 

  23. Kaminer, B., J. Mol. Biol., 39, 257 (1969).

    Article  CAS  Google Scholar 

  24. Elliott, G. F., Proc. Roy. Soc., B, 160, 467 (1964).

    Article  ADS  CAS  Google Scholar 

  25. Elliott, G. F., J. Gen. Physiol., 50 (Suppl.), 171 (1967).

    Article  Google Scholar 

  26. Lowy, J., Poulsen, F. R., and Vibert, P. J., Nature, 225, 1053 (1970).

    Article  ADS  CAS  Google Scholar 

  27. Elliott, G. F., and Lowy, J., Nature, 219, 156 (1968).

    Article  ADS  CAS  Google Scholar 

  28. Loewy, A. G., J. Cell. Comp. Physiol., 40, 127 (1952).

    Article  CAS  Google Scholar 

  29. Ts'o, P. O. P., Bonner, J., Eggman, L., and Vinograd, J., J. Gen. Physiol., 39, 325 (1956).

    Article  CAS  Google Scholar 

  30. Hatano, S., and Oosawa, F., J. Cell. Physiol., 68, 197 (1966).

    Article  CAS  Google Scholar 

  31. Adelman, M. R., and Taylor, E. W., Biophys. J., 7, Suppl., 27 (1967).

    Google Scholar 

  32. Hatano, S., and Tazawa, M., Biochim. Biophys. Acta, 154, 507 (1968).

    Article  CAS  Google Scholar 

  33. Kamiya, N., Symp. Soc. Exp. Biol., 22, 199 (1968).

    CAS  PubMed  Google Scholar 

  34. Jones, B. M., Nature, 212, 362 (1966).

    Article  ADS  CAS  Google Scholar 

  35. Senda, N., Shibata, N., Tatsumi, N., Kondo, K., and Hamado, K., Biochim. Biophys. Acta, 181, 191 (1969).

    Article  CAS  Google Scholar 

  36. Franks, L. M., Riddle, P. N., and Seal, P., Exp. Cell Res., 54, 157 (1969).

    Article  CAS  Google Scholar 

  37. Ishikawa, H., Bischoff, R., and Holtzer, H., J. Cell Biol., 43, 312 (1969).

    Article  CAS  Google Scholar 

  38. Spencer, M., and Worthington, C. R., Nature, 187, 388 (1960).

    Article  ADS  CAS  Google Scholar 

  39. Elliott, G. F., Lowy, J., and Millman, B. M., J. Mol. Biol., 25, 31 (1967).

    Article  CAS  Google Scholar 

  40. Worthington, C. R., J. Mol. Biol., 1, 398 (1961).

    Article  Google Scholar 

  41. Elliott, G. F., Lowy, J., and Worthington, C. R., J. Mol. Biol., 6, 295 (1963).

    Article  Google Scholar 

  42. Rome, E., J. Mol. Biol., 27, 591 (1967).

    Article  CAS  Google Scholar 

  43. Rome, E., J. Mol. Biol., 37, 331 (1968).

    Article  CAS  Google Scholar 

  44. Elliott, G. F., J. Theoret. Biol., 21, 71 (1968).

    Article  CAS  Google Scholar 

  45. Elliott, G. F., and Rome, E., in Molecular Crystals and Liquid Crystals, 8, 215 (Gordon and Breach, 1969).

    Google Scholar 

  46. Elliott, G. F., and Rome, E., Biophys. J., 9, A–97 (1969).

    Google Scholar 

  47. Spencer, M., Nature, 223, 1361 (1969).

    Article  ADS  CAS  Google Scholar 

  48. Huxley, H. E., in The Cell (edit. by J. Brachet and A. Mirsky), 4, 365 (Academic Press, New York, 1960).

    Google Scholar 

  49. Huxley, H. E., and Brown, W., J. Mol. Biol., 30, 383 (1967).

    Article  CAS  Google Scholar 

  50. Hill, D. K., J. Physiol., 199, 637 (1968).

    Article  CAS  Google Scholar 

  51. Shear, D. B., Physiol. Chem. and Physics, 1, 495 (1969).

    CAS  Google Scholar 

  52. Ullrick, W. C., J. Theoret. Biol., 15, 53 (1967).

    Article  CAS  Google Scholar 

  53. Elliott, G. F., and Lowy, J., J. Mol. Biol., 3, 41 (1961).

    Article  CAS  Google Scholar 

  54. Huxley, H. E., Proc. Roy. Soc., B, 141, 59 (1953).

    Article  ADS  CAS  Google Scholar 

  55. Elliott, G. F., Lowy, J., and Millman, B. M., Nature, 206, 1357 (1965).

    Article  ADS  CAS  Google Scholar 

  56. April, E., and Elliott, G. F., Abst. Third Intern. Cong., International Union for Pure and Applied Biophysics, 119 (1969).

  57. Bernal, J. D., Symp. Soc. Exp. Biol., 19, 17 (1965).

    CAS  PubMed  Google Scholar 

  58. Ernst, E., in Biophysics of the Striated Muscle (Akadémiai Kiadó), (Budapest, 1963).

    Google Scholar 

  59. Robinson, J. R., Physiol. Rev., 40, 112 (1960).

    Article  CAS  Google Scholar 

  60. Reuben, J. P., Lopez, E., Brandt, P. W., and Grundfest, H., Science, 142, 246 (1963).

    Article  ADS  Google Scholar 

  61. Blinks, J. R., J. Physiol., 177, 42 (1965).

    Article  CAS  Google Scholar 

  62. Bratton, C. B., Hopkins, A. L., and Weinberg, J. W., Science, 147, 738 (1965).

    Article  ADS  CAS  Google Scholar 

  63. Cope, F. W., Biophys. J., 9, 303 (1969).

    Article  ADS  CAS  Google Scholar 

  64. Hazelwood, C. F., Nichols, B. L., and Chamberlain, N. F., Nature, 222, 747 (1969).

    Article  ADS  Google Scholar 

  65. Weber, H. H., and Portzehl, H., Prog. Biophys. Biophys. Chem., 4, 60 (1954).

    Article  Google Scholar 

  66. Svedberg, T., and Pedersen, K. O., The Ultracentrifuge, 29 (Johnson Reprint, New York, 1959).

  67. Huxley, H. E., J. Mol. Biol., 7, 281 (1963).

    Article  CAS  Google Scholar 

  68. Huxley, H. E., J. Mol. Biol., 37, 507 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. G. F. ELLIOTT

    Present address: The Open University, Walton Hall, Bletchley, Buckinghamshire

Authors and Affiliations

  1. MRC Biophysics Unit, 26–29 Drury Lane, London, WC2

    G. F. ELLIOTT, E. M. ROME & M. SPENCER

Authors
  1. G. F. ELLIOTT
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  2. E. M. ROME
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  3. M. SPENCER
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ELLIOTT, G., ROME, E. & SPENCER, M. A Type of Contraction Hypothesis applicable to all Muscles. Nature 226, 417–420 (1970). https://doi.org/10.1038/226417a0

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