Abstract
DIMETHYLAMINONAPHTHYL sulphonyl chloride (dansyl chloride) has been used in recent years as an end group analytical reagent in the study of protein structure1 and in the determination of amino-acids2–4. Dansyl chloride reacts with primary and secondary amines and with phenolic hydroxyl groups4. Chlorpromazine, after administration to patients, yields over twenty known metabolites5. At least ten of these metabolites possess either an amino or a phenolic hydroxyl group, or both, as potential reactive sites for dansyl chloride coupling. We have studied the reactivity of dansyl chloride with the chlorpromazine metabolites listed in Table 1.
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KAUL, P., CONWAY, M. & CLARK, M. Sensitive Quantitative Determination of Chlorpromazine Metabolites. Nature 226, 372–373 (1970). https://doi.org/10.1038/226372a0
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DOI: https://doi.org/10.1038/226372a0
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