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Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in Mice

Nature volume 226, pages 1257–1258 (1970)Cite this article

Abstract

THERE is now good evidence that the theta (θ) isoantigen of mice1 is carried only by those peripheral lymphocytes which are thymus-derived2–4, so that anti-θ antiserum should be useful in elucidating the role of these cells in immunity. In experiments reported here, anti-θ has been used in vitro in an adoptive transfer system5 to study the function of thymus-derived lymphocytes in the secondary humoral immune response to hapten–protein conjugates, particularly in terms of cellular cooperation and carrier effects.

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References

  1. Reif, A. E., and Allen, J. M., J. Exp. Med., 120, 413 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Schlesinger, M., and Yron, I., Science, 164, 1412 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Raff, M. C., Nature, 224, 378 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Raff, M. C., and Wortis, H. H., Immunology (in the press).

  5. Mäkelä, O., and Mitchison, N. A., Immunology, 8, 549 (1965).

    PubMed  PubMed Central  Google Scholar 

  6. Brownstone, A., Mitchison, N. A., and Pitt-Rivers, R., Immunology, 10, 465 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Brownstone, A., Mitchison, N. A., and Pitt-Rivers, R., Immunology, 10, 481 (1966).

    CAS  PubMed Central  Google Scholar 

  8. Mitchison, N. A., Proc. Roy. Soc., B, 161, 275 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Mitchison, N. A., in Differentiation and Immunology (edit. by Warren, K. B.), 29 (Academic Press, New York, 1968).

    Book  Google Scholar 

  10. Mitchison, N. A., Rajewsky, K., and Taylor, R. B., in Symp. Developmental Aspects of Antibody Formation and Structure, Prague (in the press).

  11. Ovary, Z., and Benacerraf, B., Proc. Soc. Exp. Biol. NY, 114, 72 (1963).

    Article  CAS  Google Scholar 

  12. Rajewsky, K., Schirrmacher, V., Nase, S., and Jerne, N. K., J. Exp. Med., 129, 1131 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Taylor, R. B., Transplant. Rev., 1, 43 (1969).

    Google Scholar 

Download references

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  1. National Institute for Medical Research, Mill Hill, London, NW7

    MARTIN C. RAFF

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  1. MARTIN C. RAFF
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RAFF, M. Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in Mice. Nature 226, 1257–1258 (1970). https://doi.org/10.1038/2261257a0

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