Abstract
IT has been shown that the rate of mitosis in the pronephric kidney of larval Xenopus is inhibited by factors present in soluble fractions of homogenized adult Xenopus kidney (mesonephros) or rat kidney (metanephros)3,10 and it was suggested that the rate of cell division in the kidney may be controlled by a tissue-specific mitotic inhibitor or chalone such as has been described in other tissues1,9,11,13. Although the rate of mitosis in the larval pronephros is sensitive to the “kidney chalone” we do not know whether it is controlled by the chalone in natural conditions, because this would imply that the pronephros already produces the chalone at this early stage in development. Extraction of the chalone from such a small organ would be difficult and we have therefore sought a different way of demonstrating its presence.
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References
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CHOPRA, D., SIMNETT, J. Stimulation of Mitosis in Amphibian Kidney by Organ Specific Antiserum. Nature 225, 657–658 (1970). https://doi.org/10.1038/225657a0
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DOI: https://doi.org/10.1038/225657a0
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