Abstract
IT has frequently been suggested that the chemical properties of phospholipids and their prevalence in cell membranes make them particularly suitable compounds to serve as carrier molecules for the transport of cations. Some support for this suggestion has been provided by studies of the cation binding properties of phospholipids1,2 and of various model systems involving phospholipids3–5. Taken together, these investigations indicated that some phospholipids might be especially concerned in the active transport of Na+ and K+, but the evidence is not conclusive. The concept of such a carrier for ion transport antedates the work showing the involvement of ATP and its enzymatic hydrolysis in the Na+ pump; and during the past decade there has been a shift of interest and emphasis towards the role of the membrane ATPase system in active cation transport6. During this period, however, evidence has accumulated that the Na+, K+-activated ATPase is eliminated when lipids are removed from membranes by solvent extraction, treatment with detergents, or exposure to phospholipases7–9. The question therefore arises whether phospholipid might provide a carrier system in which the protein of the ATPase is also involved, such that the ATPase activity depends on lipid as well as protein.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Solomon, A. K., Lionetti, F., and Curran, P. F., Nature, 178, 582 (1956).
Kirschner, L. B., J. Gen. Physiol., 42, 231 (1958).
Hoffman, J. F., Schulman, J. H., and Eden, M., Fed. Proc., 18, 70 (1959).
Tobias, J. M., Agin, D. P., and Pawlowski, R., J. Gen. Physiol., 45, 989 (1962).
Papahadjopoulos, D., and Bangham, A. D., Biochim. Biophys. Acta, 126, 185 (1966).
Glynn, I. M., Brit. Med. Bull., 24, 165 (1968).
Askari, A., and Frantantoni, J. C., Biochim. Biophys. Acta, 92, 132 (1964).
Emmelot, P., and Bos, C. J., Biochim. Biophys. Acta, 120, 369 (1966).
Schatzmann, H. J., Nature, 196, 677 (1962).
Tanaka, R., and Abood, L. G., Arch. Biochem. Biophys., 108, 47 (1964).
Tanaka, R., and Strickland, K. P., Arch. Biochem. Biophys., 111, 583 (1965).
Fenster, L. J., and Copenhaver, J. H., Biochim. Biophys. Acta, 137, 406 (1967).
Emmelot, P., and Bos, C. J., Biochim. Biophys. Acta, 150, 341 (1968).
Ohnishi, T., and Kawamura, H., J. Biochem. Tokyo, 56, 377 (1964).
Formby, B., and Clausen, J., Z. Physiol. Chem., 349, 909 (1968).
Tanaka, R., and Mitsumata, T., J. Neurochem., 16, 1163 (1969).
Tanaka, R., J. Neurochem., 16, 1301 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WHEELER, K., WHITTAM, R. ATPase Activity of the Sodium Pump needs Phosphatidylserine. Nature 225, 449–450 (1970). https://doi.org/10.1038/225449a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/225449a0
This article is cited by
-
Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension
BMC Neurology (2011)
-
Effects of Exogenous Phosphatidylserine on Cognitive Functions and Phospholipid Metabolism in the Hippocampus of Aged Rats
Neuroscience and Behavioral Physiology (2011)
-
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men
European Journal of Clinical Pharmacology (1992)
-
Trinitrobenzenesulfonic acid and fluorodinitrobenzene: Probes to study local anesthetic effects in cell membranes
The Journal of Membrane Biology (1981)
-
Pharmacological effects of phosphatidylserine liposomes
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.