Abstract
WE have been studying the mechanism of tyrosine amino-transferase (TAT) induction by adrenal steroids in hepatoma (HTC) cell cultures1,2. The hormones increase the rate of enzyme synthesis resulting in an increased intracellular TAT concentration3. The enzyme is continuously turning over with a half-time of degradation of 3 to 7 h (measured as loss of either enzymic or antigenic activity), depending on the experiment and the conditions.
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References
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AURICCHIO, F., MARTIN, D. & TOMKINS, G. Control of Degradation and Synthesis of Induced Tyrosine Aminotransferase studied in Hepatoma Cells in Culture. Nature 224, 806–808 (1969). https://doi.org/10.1038/224806b0
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DOI: https://doi.org/10.1038/224806b0
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