Abstract
ALAMETHICIN, a cyclic polypeptide antibiotic produced by Trichoderma viride1,2, induces “action potentials” in bimolecular lipid membranes3, and ion movements and energy-linked K+ accumulation in mitochondria4. These properties are relevant to membrane function in general and ion transport, nerve impulses and antibiotic action in particular, and more information on other chemical and physical properties of alamethicin may show how they could contribute to its excitability inducing effects in experimental bilayers. When the effects occur, phospholipids are also present. We now report some physical properties of and black film results with alamethicin, and a study of phospholipid/alamethicin interactions.
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CHAPMAN, D., CHERRY, R., FINER, E. et al. Physical Studies of Phospholipid/Alamethicin Interactions. Nature 224, 692–694 (1969). https://doi.org/10.1038/224692a0
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DOI: https://doi.org/10.1038/224692a0
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