Abstract
THE proliferative activity of an acute leukaemic blast cell population will depend on the respective sizes of its proliferating and non-proliferating compartments. Proliferating blasts have no self-maintaining kinetic pattern1, but after one or two divisions become much smaller and enter the non-proliferating compartment2–4. An important question raised by this new evidence is, what is the fate of these small, non-proliferating blasts ? Are they end cells, destined to die as such, or are they only apparently mature, retaining a latent potential for division ? The experiment reported here was done to test whether the small blasts forming part of the non-proliferating compartment retained the potential to proliferate.
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GABUTTI, V., PILERI, A., TAROCCO, R. et al. Proliferative Potential of Out-of-cycle Leukaemic Cells. Nature 224, 375–376 (1969). https://doi.org/10.1038/224375a0
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DOI: https://doi.org/10.1038/224375a0
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