Abstract
THE genome is a complex net of interacting components commonly thought to control homeostasis and differentiation through precisely constructed control circuits among the genes1–6. But I have found what seems to be a new class of dynamically stable systems, which suggests that even haphazardly constructed control nets of high molecular specificity undergo homeostasis and differentiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Apter, M. J., Cybernetics and Development (Pcrgamon Press, Oxford, 1966).
Bonner, J. F., The Molecular Biology of Development (Oxford University Press, London, 1965).
Jacob, F., and Monod, J., Twenty-first Symp. Soc. Study of Development and Growth (Academic Press, London, 1963).
Sugita, M., J. Theoret. Biol., 4, 179 (1963).
Kauffman, S. A., J. Theoret. Biol., 17, 483 (1967).
Goodwin, B. C., Temporal Organization in Cells (Academic Press, London. 1963).
Kauffman, S. A., J. Theoret. Biol., 22, 437 (1969).
Bretscher, M. S., Nature, 217, 509 (1967).
Bullough, W. S., The Evolution of Differentiation (Academic Press. London. 1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KAUFFMAN, S. Homeostasis and Differentiation in Random Genetic Control Networks. Nature 224, 177–178 (1969). https://doi.org/10.1038/224177a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/224177a0
This article is cited by
-
Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis
npj Systems Biology and Applications (2024)
-
Networks of Classical Conditioning Gates and Their Learning
New Generation Computing (2024)
-
Steady-State Analysis of p53 Protein Pathway Using DTMC and CTMC
Transactions of the Indian National Academy of Engineering (2023)
-
Differentiable learning of matricized DNFs and its application to Boolean networks
Machine Learning (2023)
-
Degeneracy measures in biologically plausible random Boolean networks
BMC Bioinformatics (2022)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.