Abstract
IMMUNOLOGICAL and chemotherapeutic studies of human malaria in primates have been hampered by an inability to establish a reliable sporozoite passage of parasites. Although sporozoite transmission of falciparum and vivax malaria has been achieved in Aotus trivirgatus1,2, only a single mosquito–Aotus–mosquito cycle of the Achiote (Panama) isolate of Plasmodium vivax has been reported3. Attempts to reinfect Aotus with this strain by mosquito bite failed, although a human volunteer was reinfected by this route.
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WARD, R., RUTLEDGE, L. & HICKMAN, R. Cyclical Transmission of Chesson Vivax Malaria in Subhuman Primates. Nature 224, 1126–1127 (1969). https://doi.org/10.1038/2241126a0
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DOI: https://doi.org/10.1038/2241126a0
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