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Cell Transformation by Polyoma Virus and SV40

Abstract

Heritable alterations in cell growth after infection by viruses usually lead to malignancy, and consequently are attracting a great deal of attention. This review brings the story up to date and poses some questions for the future.

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References

  1. Eckhart, W., Physiol. Revs., 48, 513 (1968).

    Article  CAS  Google Scholar 

  2. Black, P., Ann. Rev. Microbiol., 22, 391 (1968).

    Article  CAS  Google Scholar 

  3. Crawford, L., Adv. Virus Res., 14, 89 (1969).

    Article  CAS  PubMed  Google Scholar 

  4. Winocour, E., Adv. Virus Res., 14, 153 (1969).

    Article  CAS  PubMed  Google Scholar 

  5. Fogel, M., and Defendi, V., Proc. US Nat. Acad. Sci., 58, 967 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Black, P. H., Virology, 28, 760 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. Burger, M. M., and Goldberg, A. R., Proc. US Nat. Acad. Sci., 57, 359 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Inbar, M., and Sachs, L., Nature, 223, 710 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Rapp, F., and Melnick, J. F., Prog. Med. Virol., 8, 349 (1966).

    CAS  PubMed  Google Scholar 

  10. Rapp, F., Ann. Rev. Microbiol. (in the press, 1969).

  11. Eckhart, W., Virology, 38, 120 (1969).

    Article  CAS  PubMed  Google Scholar 

  12. diMayorca, G., Callender, J., Marin, G., and Giordano, R., Virology, 38, 126 (1969).

    Article  CAS  Google Scholar 

  13. Stoker, M., and Dulbecco, R., Nature, 223, 397 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Westphal, H., and Dulbecco, R., Proc. US Nat. Acad. Sci., 59, 1158 (1968).

    Article  ADS  CAS  Google Scholar 

  15. Sambrook, J., Westphal, H., Srinivasan, P. R., and Dulbecco, R., Proc. US Nat. Acad. Sci., 60, 1288 (1968).

    Article  ADS  CAS  Google Scholar 

  16. Marin, G., and Littlefield, J. W., J. Virol., 2, 69 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Weiss, M., Ephrussi, B., and Scaletta, L., Proc. US Nat. Acad. Sci., 59, 1132 (1968).

    Article  ADS  CAS  Google Scholar 

  18. Pollack, R. E., Green, H., and Todaro, G., Proc. US Nat. Acad. Sci., 60, 126 (1968).

    Article  ADS  CAS  Google Scholar 

  19. Rabinowitz, Z., and Sachs, L., Virology, 38, 336 (1969).

    Article  CAS  PubMed  Google Scholar 

  20. Oda, K., and Dulbecco, R., Proc. US Nat. Acad. Sci., 60, 525 (1968).

    Article  ADS  CAS  Google Scholar 

  21. Aloni, Y., Winocour, E., and Sachs, L., J. Mol. Biol., 31, 415 (1968).

    Article  CAS  PubMed  Google Scholar 

  22. Sauer, G., and Kidwai, J. R., Proc. US Nat. Acad. Sci., 61, 1256 (1968).

    Article  ADS  CAS  Google Scholar 

  23. Martin, M. A., and Axelrod, D., Science, 164, 68 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Dubbs, D. R., and Kit, S., J. Virol., 2, 1272 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Koprowski, H., Jensen, F. C., and Steplewski, Z., Proc. US Nat. Acad. Sci., 58, 127 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Jensen, F. C., and Koprowski, H., Virology, 37, 687 (1969).

    Article  CAS  PubMed  Google Scholar 

  27. Burgess, R. R., Travers, A. A., Dunn, J. J., and Bautz, E. K. F., Nature, 221, 43 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Bautz, E. K. F., Bautz, F. A., and Dunn, J. J., Nature, 223, 1022 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

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ECKHART, W. Cell Transformation by Polyoma Virus and SV40. Nature 224, 1069–1071 (1969). https://doi.org/10.1038/2241069a0

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