Abstract
WE have compared the bronchodilator activities of aerosols of prostaglandin E1 (PGE1) and isoprenaline in the anaesthetized guinea-pig. Although PGE1 was slightly less potent than isoprenaline on intravenous administration, it had some 10–100 times the bronchodilator activity of isoprenaline when given by aerosol.
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References
Ferreira, S. H., and Vane, J. R., Nature, 216, 868 (1967).
Rosenthale, M. E., Dervinis, A., Begany, A. J., Lapidus, M., and Gluckman, M. I., The Pharmacologist, 10, 175 (1968).
Speizer, F. E., Doll, R., Heaf, P., and Strang, L. B., Brit. Med. J., i, 339 (1968).
Brit. Med. J., i, 329 (1968).
Paterson, J. W., Conolly, M. E., Davies, D. S., and Dollery, C. T., Lancet, ii, 426 (1968).
Cuthbert, M. F., Fourth Intern. Cong. Pharmacol. Abstr., 113 (1969).
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LARGE, B., LESWELL, P. & MAXWELL, D. Bronchodilator Activity of an Aerosol of Prostaglandin E1 in Experimental Animals. Nature 224, 78–80 (1969). https://doi.org/10.1038/224078a0
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DOI: https://doi.org/10.1038/224078a0
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