Abstract
SEVERAL viruses have been reported to induce immunological tolerance in mice when administered in the immediate postnatal period. Among these are the lymphocytic choriomeningitis (LCM) virus1,2 and the murine leukaemogenic viruses3–5. Moloney leukaemogenic virus (MLV) induces lymphocytic leukaemia in both newborn and adult mice6. Inoculation of adults with MLV results, however, in the development of both humoral and cell-mediated immune responses to the virus, whereas in neonatally infected mice these responses are greatly reduced or undetectable4,7.
Similar content being viewed by others
Article PDF
References
Hotchin, J., Cold Spring Harbor Symp. Quant. Biol., 27, 479 (1962).
Volkert, M., and Hannover-Larsen, J., Prog. Med. Virol., 7, 160 (1965).
Axelrad, A. A., Prog. Exp. Tumour Res., 6, 30 (1965).
Klein, E., and Klein, G., Nature, 209, 163 (1966).
Chieco-Bianchi, L., Tridente, G., Pennelli, N., and Fiore-Donati, L., Bibl. Haemat., 31, 40 (1968).
Moloney, J. B., Nat. Cancer Inst. Monog., 4, 7 (1960).
Klein, E., and Klein, G., Cancer Res., 25, 851 (1965).
Oldstone, M. B. A., and Dixon, F. J., Science, 158, 1193 (1967).
Oldstone, M. B. A., and Dixon, F. J., J. Exp. Med., 129, 483 (1969).
Harvey, J. J., J. Gen. Virol., 3, 327 (1968).
Guttman, P. H., and Kohn, H. I., Amer. J. Pathol., 37, 293 (1960).
Hirsch, M. S., and Harvey, J. J., Intern. J. Cancer (in the press).
Notkins, A. L., Mahar, S., Scheele, C., and Goffman, J., J. Exp. Med., 124, 81 (1966).
Hirsch, M. S., Murphy, F. A., and Hicklin, M. D., J. Exp. Med., 127, 757 (1968).
Recher, L., Tanaka, T., Sykes, J. A., Yumoto, T., Seman, G., Young, L., and Dmochowski, L., Nat. Cancer Inst. Monog., 22, 459 (1966).
Dunn, T. B., and Green, A. W., J. Nat. Cancer Inst., 36, 987 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HIRSCH, M., ALLISON, A. & HARVEY, J. Immune Complexes in Mice infected neonatally with Moloney Leukaemogenic and Murine Sarcoma Viruses. Nature 223, 739–740 (1969). https://doi.org/10.1038/223739a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/223739a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.