Use of Citrate in mobilizing Plutonium in Rat


PLUTONIUM in the blood plasma of man and rat is believed to be associated readily as a chelate with the (β-globulin transferrin1,2, but studies with citrate ions have shown that when the plasma citrate concentration exceeds 10 mg per 100 ml., plutonium citrate is formed in preference to the plutonium–transferrin complex2. Artificial loading of blood with tri-sodium citrate to above 10 mg/100 ml. is possible in the intact animal with little toxic reaction, as has been shown for man3. We report the results of an experiment designed to evaluate the use of citrate in the treatment of acute plutonium poisoning with a view to extrapolating the data to humans.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Stover, B. J., Atherton, D. R., and Kellar, N., Radiat. Res., 10, 130 (1959).

  2. 2

    Boocock, C., and Popplewell, D. S., AWRE Report No. 0–37/66 (1966).

  3. 3

    Ludbrook, J., and Wynn, V., Brit. Med. J., ii, 523 (1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

SMITH, H., CHAPMAN, I. Use of Citrate in mobilizing Plutonium in Rat. Nature 223, 642–643 (1969).

Download citation


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.