Abstract
PLUTONIUM in the blood plasma of man and rat is believed to be associated readily as a chelate with the (β-globulin transferrin1,2, but studies with citrate ions have shown that when the plasma citrate concentration exceeds 10 mg per 100 ml., plutonium citrate is formed in preference to the plutonium–transferrin complex2. Artificial loading of blood with tri-sodium citrate to above 10 mg/100 ml. is possible in the intact animal with little toxic reaction, as has been shown for man3. We report the results of an experiment designed to evaluate the use of citrate in the treatment of acute plutonium poisoning with a view to extrapolating the data to humans.
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References
Stover, B. J., Atherton, D. R., and Kellar, N., Radiat. Res., 10, 130 (1959).
Boocock, C., and Popplewell, D. S., AWRE Report No. 0–37/66 (1966).
Ludbrook, J., and Wynn, V., Brit. Med. J., ii, 523 (1958).
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SMITH, H., CHAPMAN, I. Use of Citrate in mobilizing Plutonium in Rat. Nature 223, 642–643 (1969). https://doi.org/10.1038/223642a0
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DOI: https://doi.org/10.1038/223642a0
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