Infectivity of Chloroquine Resistant Plasmodium berghei to Anopheles stephensi enhanced by Chloroquine

Abstract

DRUG resistance is an increasing problem in parts of South America and South-East Asia where numerous strains of the malignant tertian malaria parasite, Plasmodium falciparum, are refractory to chloroquine and other widely used antimalarials1. The rapidity with which new chloroquine-resistant strains are being recognized suggests that they may have, as well as drug resistance, some biological advantage over the accompanying sensitive falciparum parasites either in the vertebrate host (man) or the invertebrate host (certain species of Anopheles mosquitoes).

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RAMKARAN, A., PETERS, W. Infectivity of Chloroquine Resistant Plasmodium berghei to Anopheles stephensi enhanced by Chloroquine. Nature 223, 635–636 (1969). https://doi.org/10.1038/223635a0

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