Abstract
IN 1967, one of us (W. L.) received numerous reports from veterinary surgeons of anaphylactic shock or generalized urticaria occurring in cows a few minutes after injection of therapeutic doses of various drugs, but mostly of penicillin preparations. Such reactions have been encountered in Switzerland (and America1) before, but the incidence increased markedly in the months following a vaccination campaign against foot and mouth disease during the winter 1966–67.
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References
De Quiroz, R., Sutmöller, P., and Barroete, F. M., Amer. J. Vet. Res., 25, 1627 (1964).
Idsøe, O., Guthe, T., Willcox, R. R., and De Weck, A. L., Bull. WHO, 38, 159 (1968).
De Weck, A. L., Intern. Arch. Allergy, 21, 20 (1962).
De Weck, A. L., Nature, 202, 975 (1964).
De Weck, A. L., in Immunopathology (edit. by Miescher, P. A., and Grabar, P.), 295 (1967).
De Weck, A. L., Schneider, C. H., and Gutersohn, J., Intern. Arch. Allergy, 33, 535 (1968).
McCollister, D. D., and Oyen, F., J. Amer. Pharmaceut. Assoc., Sci. Ed., 43, 664 (1954).
Platt, D., Bicanovsky, J. E., Dalbow, M. H., and Thonard, J. C., Nature, 209, 214 (1966).
Olovnikov, A. M., and Gurvich, A. E., Nature, 209, 417 (1966).
Stegemann, H., and Loeschke, V., Z. Physiol. Chem., 329, 240 (1962).
Gill, T. J., Kunz, H. W., and Papermaster, D. S., J. Biol. Chem., 242, 3308 (1967).
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LEEMANN, W., DE WECK, A. & SCHNEIDER, C. Hypersensitivity to Carboxymethyl-cellulose as a Cause of Anaphylactic Reactions to Drugs in Cattle. Nature 223, 621–623 (1969). https://doi.org/10.1038/223621a0
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DOI: https://doi.org/10.1038/223621a0
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