Diminished Responsiveness to Thyroid Hormone in Riboflavin-deficient Rats

Abstract

THE hepatic activity of mitochondrial α-glycerophosphate dehydrogenase can be up to 100-fold greater in hyperthyroid rats than thyroidectomized rats1. Both the thyroid hormones, thyroxine or triiodothyronine, or their analogues, enhance enzyme activity and enhancement is blocked by simultaneous administration of actinomycin D and/or puromycin2,3. The enhancement has been suggested as a test for thyroid function4. Here we report that both the basal activity of the enzyme and the maximal activity induced by triiodothyronine are dependent upon adequate dietary intake of riboflavin.

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References

  1. 1

    Lee, Y.-P., and Lardy, H. A., J. Biol. Chem., 240, 1427 (1965).

  2. 2

    Lee, K.-L., and Miller, O. N., Mol. Pharmacol., 3, 44 (1967).

  3. 3

    Lee, K.-L., Sellinger, O. Z., and Miller, O. N., Proc. Soc. Exp. Biol. and Med., 126, 169 (1967).

  4. 4

    Richert, D. A., Schenkman, J., and Westerfeld, W. W., J. Nutrition, 83, 332 (1964).

  5. 5

    Rivlin, R. S., and Levine, R. G., Endocrinology, 73, 103 (1963).

  6. 6

    Lee, K.-L., and Miller, O. N., Arch. Biochem. Biophys., 120, 638 (1967).

  7. 7

    Ringler, R. L., and Singer, T. P., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 432 (Academic Press, New York, 1962).

  8. 8

    Prosky, L., Burch, H. B., Bejrablaya, D., Lowry, O. H., and Combs, A. M., J. Biol. Chem., 239, 2691 (1964).

  9. 9

    Burch, H. B., Lowry, O. H., Padilla, A. M., and Combs, A. M., J. Biol. Chem., 223, 29 (1956).

  10. 10

    Rivlin, R. S., Menendez, C., and Langdon, R. G., Endocrinology, 83, 461 (1968).

  11. 11

    Rivlin, R. S., and Langdon, R. G., in Advances in Enzyme Regulation (edit. by Weber, G.), 4, 45 (Pergamon Press, Oxford, 1966).

  12. 12

    Burch, H. B., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 960 (Academic Press, New York, 1957).

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RIVLIN, R., WOLF, G. Diminished Responsiveness to Thyroid Hormone in Riboflavin-deficient Rats. Nature 223, 516–517 (1969). https://doi.org/10.1038/223516a0

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