Abstract
PREVIOUS studies in amelogenesis have shown that the organic matrix of enamel undergoes marked changes during development. These include a loss of protein and a change in the amino-acid composition1–3. Experiments with labelled protein precursors show that label first appears in a discrete layer in the enamel but soon spreads throughout the matrix4,5. Only tentative explanations for such processes have so far been put forward2,3. More recently, however, preliminary histochemical studies have shown that several enzymes belonging to the lysosomal system are present in ameloblasts6. Lysosomes are known to participate in both intra and extracellular degradative processes7, and it is possible that lysosomal enzymes may be the agents responsible for some of the changes observed in enamel matrix during development. We have investigated this possibility using the more powerful technique of enzyme cytochemistry combined with electron microscopy.
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KATCHBURIAN, E., HOLT, S. Role of Lysosomes in Amelogenesis. Nature 223, 1367–1368 (1969). https://doi.org/10.1038/2231367a0
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DOI: https://doi.org/10.1038/2231367a0
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