Abstract
HETEROLOGOUS antilymphocyte serum (ALS) can be a potent agent to prolong the survival of allografts of many tissues when administered to graft recipients before and after transplantation1. It has recently been claimed that pre-treatment of graft donors with ALS can prolong the survival of renal allografts in the rat2, but attempts to prolong the survival of skin allografts by donor pretreatment have been unsuccessful (unpublished results of A. D. B.). This may be because skin allografts are more demanding in their compatibility requirements than renal allografts3. To test this possibility we have studied the effect of ALS on the survival of murine ovary allografts which are known to be less immunogenic than skin allografts4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Levey, R. H., and Medawar, P. B., Proc. US Nat. Acad. Sci., 56, 1130 (1966).
Guttmann, R. D., Carpenter, C. B., Lindquist, R. R., and Mervill, J. P., Lancet, i, 249 (1967).
Barnes, A. D., Burr, W. A., and Staniforth, P., Advance in Transplantation (edit. by Daussett, J., Hamburger, J., and Mathe, G.), 343 (Munksgaard, Copenhagen, 1968).
White, E., and Hildeman, W. H., Science, 162, 1293 (1968).
Hicken, P., and Krohn, P. L., Proc. Roy. Soc., B, 151, 419 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BARNES, A., CROSIER, C. Effect of Antilymphocyte Serum on the Survival of Ovary Allografts in the Mouse. Nature 223, 1059–1060 (1969). https://doi.org/10.1038/2231059a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2231059a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
