Abstract
Lutwak-Mann and McIntosh1 demonstrated that the Zn content and carbonic anhydrase activity of the endometrium of rabbit uterus are highest 4–6 days after mating. They speculated that the increase in activity of this Zn-containing enzyme might reflect the synthesis of new protein in response to progesterone and 20α-dihydro-progesterone secreted by the rabbit ovary after mating and ovulation. Our observations, reported here, suggest a role for Zn in the binding of steroid hormones to their target tissue.
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References
Lutwak-Mann, C., and McIntosh, J. E. A., Nature, 221, 1111 (1969).
Gray, C. H., and Shaw, D. A., J. Endocrinol., 33, 33 (1965).
Korenman, S. G., J. Clin. Endocrinol., 28, 127 (1968).
Tveter, K. J., Acta Endocrinol., 60, 60 (1969).
Mawson, C. A., and Fischer, M. I., Nature, 162, 859 (1951).
Mawson, C. A., and Fischer, M. I., Arch. Biochem. Biophys., 36, 485 (1952).
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EMANUEL, M., OAKEY, R. Effect of Zn++ on the Binding of Oestradiol-17β to a Uterine Protein. Nature 223, 66–67 (1969). https://doi.org/10.1038/223066a0
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DOI: https://doi.org/10.1038/223066a0
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