Abstract
TISSUE culture lines of human tumours, including leukaemias and Burkitt lymphomas, have been successfully transplanted into newborn rats (ref. 1 and private communication from C. M. Southam). Those lines which produced human serum proteins in vitro (HEp 2 and RPMI41; HEp 2 is derived from an epidermoid carcinoma2 and RPMI from an osteogenic sarcoma3) continued to do so in the xenogeneic host, for human proteins could be demonstrated in the serum4. Reactivity was similar to that usually seen on the Daudi tissue culture cells.
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LEVIN, A., FRIBERG, S. & KLEIN, E. Xenotransplantation of a Burkitt Lymphoma Culture Line with Surface Immunoglobulin Specificity. Nature 222, 997–998 (1969). https://doi.org/10.1038/222997a0
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DOI: https://doi.org/10.1038/222997a0
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