Radiosensitization of Ehrlich Ascites Tumour Cells by a Specific Antibody

Abstract

AN antibody against the mouse Ehrlich ascites carcinoma (EAC) can be conjugated with enough ¹³¹I to prevent the in vivo growth of EAC cells exposed in vitro to the radio-iodinated antibody¹. To avoid the introduction of more than the minimum tumour-suppressive dose of the radio-iodinated antibody into EAC-bearing mice, it is necessary to determine the minimum EAC-suppressive dose of ionizing radiation acting alone or in conjunction with the anti-EAC antibody. The results presented here show that exposure of EAC cells to the anti-EAC antibody rendered them more susceptible to the tumour-suppressive effect of X-irradiation.