Letter | Published:

Radiosensitization of Ehrlich Ascites Tumour Cells by a Specific Antibody

Nature volume 222, pages 993994 (07 June 1969) | Download Citation

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Abstract

AN antibody against the mouse Ehrlich ascites carcinoma (EAC) can be conjugated with enough 131I to prevent the in vivo growth of EAC cells exposed in vitro to the radio-iodinated antibody1. To avoid the introduction of more than the minimum tumour-suppressive dose of the radio-iodinated antibody into EAC-bearing mice, it is necessary to determine the minimum EAC-suppressive dose of ionizing radiation acting alone or in conjunction with the anti-EAC antibody. The results presented here show that exposure of EAC cells to the anti-EAC antibody rendered them more susceptible to the tumour-suppressive effect of X-irradiation.

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Author information

Author notes

    • T. GHOSE
    •  & M. CERINI

    Present address: Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada

Affiliations

  1. Department of Pathology, Monash University, Melbourne, Australia.

    • T. GHOSE
    •  & M. CERINI

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DOI

https://doi.org/10.1038/222993a0

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