Letter | Published:

Angiotensin accelerates Catecholamine Biosynthesis in Sympathetically Innervated Tissues

Nature volume 222, pages 987988 (07 June 1969) | Download Citation

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Abstract

ANGIOTENSIN interacts with the sympathetic nervous system. Among the interactions which have been described are stimulation of ganglion cells1,3, central activation of the sympathico-adrenal system4,5, and a potentiation of vasoconstrictor responses caused by indirectly acting sympathomimetics6 and by sympathetic nerve stimulation7–9. It is possible that an interaction between the renin-angiotensin and the sympathetic system could play an important part in the development of primary renal hypertension. We have been investigating the effects of circulating polypeptides on sympathetic nerve function, and in particular on the biochemical events involved in the synthesis and release of noradrenaline. Here we report that angiotensin amide-II has a potent stimulating effect on catecholamine biosynthesis in a number of tissues.

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References

  1. 1.

    , and , J. Physiol., 179, 538 (1965).

  2. 2.

    , and , J. Pharmacol Exp. Ther., 159, 107 (1968).

  3. 3.

    , and , J. Pharmacol. Exp. Ther., 156, 528 (1967).

  4. 4.

    , and , Proc. Soc. Exp. Biol., 106, 834 (1961).

  5. 5.

    , and , Clin. Sci., 30, 79 (1966).

  6. 6.

    , and , Circulation Res., 12, 553 (1963).

  7. 7.

    , , and , Brit. J. Pharmacol Chemother., 22, 211 (1965).

  8. 8.

    , and , Int. J. Neuropharmacol., 4, 185 (1965).

  9. 9.

    , and , J. Pharmacol Exp. Ther., 163, 320 (1968).

  10. 10.

    , and , Biochem. Pharmacol., 17, 1581 (1968).

  11. 11.

    , , and , J. Pharmacol. Exp. Ther., 158, 373 (1967).

  12. 12.

    , and , Biochem. Pharmacol., 16, 1723 (1967).

  13. 13.

    , , , and , J. Pharmacol. Exp. Ther., 148, 1 (1965).

  14. 14.

    , and , J. Pharmacol. Exp. Ther., 160, 61 (1968).

  15. 15.

    , and , J. Clin. Invest., 41, 715 (1962).

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Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.

    • MARGARET C. BOADLE
    • , JOHN HUGHES
    •  & ROBERT H. ROTH

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DOI

https://doi.org/10.1038/222987a0

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