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New Unstable Haemoglobin Borås: β88 (F4) Leucine→Arginine

Abstract

Haemoglobin Borås has a mutation in which arginine is substituted for leucine in the haem pocket. The introduction of a positive charge into the haem pocket is probably avoided by the accommodation of the guanidinium group in an external crevice of the molecule.

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HOLLENDER, A., LORKIN, P., LEHMANN, H. et al. New Unstable Haemoglobin Borås: β88 (F4) Leucine→Arginine. Nature 222, 953–955 (1969). https://doi.org/10.1038/222953a0

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