Abstract
RIFAMPICI1, a semi-synthetic derivative of rifamycin2 which was isolated from Streptomyces mediterraneus, is a clinically useful, orally active antibiotic3–5. It inhibits bacterial RNA synthesis in vivo6,7 and in vitro8–11 by interacting directly with the DNA-dependent RNA polymerase8,11. While rifampicin inhibits bacterial RNA polymerase, it does not affect in vitro the activity of mammalian RNA polymerase9,10.
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References
Maggi, N., Pasqualucci, C. R., Ballotta, R., and Sensi, P., Chemotherapia, 11, 285 (1966).
Sensi, P., Margalith, P., and Timbal, M. T., Il Farmaco, 14, 146 (1959).
Arioli, V., Pallanza, R., Furesz, S., and Carniti, G., Arzneim. Forsch. (Drug. Res.), 17, 523 (1967).
Pallanza, R.,, Arioli, V., Furesz, S., and Bolzoni, G., Arzneim. Forsch. (Drug Res.), 17, 529 (1967).
Furesz, S., Scotti, R., Pallanza, R., and Mapelli, E., Arzneim. Forsch. (Drug Res.), 17, 726 (1967).
Frontali, L., Leoni, L., and Tecce, G., Nature, 203, 84 (1964).
Lancini, G. C., and Sartori, G., Experientia, 24, 1105 (1968).
Hartmann, G., Honikel, K. O.,, Knüsel, F., and Nüesh, J., Biochim. Biophys. Acta, 145, 843 (1967).
Wehrli, W., Nüesh, J., Knüsel, F., and Staehelin, M., Biochim. Biophys. Acta, 157, 215 (1968).
Umezawa, H., Staoshi, M., Yamazaki, H., and Nitta, K., J. Antibiotics, 21, 234 (1968).
Tocchini-Valentini, G. P., Marino, P., and Colvill, A. J., Nature, 220, 275 (1968).
Kates, J. R., and McAuslan, B. R., Proc. US Nat. Acad. Sci., 58, 134 (1967).
Fromageot, H. P. M., and Zinder, N. D., Proc. US Nat. Acad. Sci., 61, 184 (1968).
Bergamini, N., and Fowst, G., Arzneim. Forsch. (Drug Res.), 15, 951 (1965).
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HELLER, E., ARGAMAN, M., LEVY, H. et al. Selective Inhibition of Vaccinia Virus by the Antibiotic Rifampicin. Nature 222, 273–274 (1969). https://doi.org/10.1038/222273a0
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DOI: https://doi.org/10.1038/222273a0
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