Letter | Published:

DNA Synthesis by Antibody-forming Cells during the Primary Immune Response

Naturevolume 222pages12951296 (1969) | Download Citation

Subjects

Abstract

THE mechanism of the rapid increase in specific antibody-producing cells during the primary immune response may involve cell division, cell “recruitment”, or a combination of both. The use of mitotic blocking agents has indicated that very rapid cell division, stimulated by antigen, alone accounts for the rapid increase in haemolytic plaque-forming cells during the primary response by the mouse to sheep erythrocytes1. Several autoradiographic studies were also interpreted to indicate an antigen-stimulated increase in the rate of division by plaque-forming cells during the primary response2,3. One group has, however, interpreted its own and other autoradiographic data to indicate that antigen does not stimulate more rapid division by plaque-forming cells4,5. Two of these studies2,5 involved examination of plaque-forming cells only, sampled on one day. The other two studies3,4 were severely limited in sensitivity by the technique for examining DNA synthesis—continuous exposure to 3H-thymidine from the time of antigen administration to the time of death.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Rowley, D. A., Fitch, F. W., et al., J. Exp. Med., 127, 983 (1968).

  2. 2

    Koros, A. M. C., Fuji, H., and Jerne, N. K., Fed. Proc., 25, 305 (1966, abstract).

  3. 3

    Szenberg, A., and Cunningham, A. J., Nature, 217, 747 (1968).

  4. 4

    Tannenberg, W. J. K., Nature, 214, 293 (1967).

  5. 5

    Tannenberg, W. J. K., and Malaviya, A. N., J. Exp. Med., 128, 895 (1968).

  6. 6

    Mishell, R. I., and Dutton, R. W., Science, 153, 1004 (1966).

  7. 7

    Barka, T., and Anderson, P. J., Histochemistry, 106 (Hoeber, New York, 1963).

Download references

Author information

Author notes

    • ROBERT E. KRISCH

    Present address: Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, 60439

Affiliations

  1. US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland

    • ROBERT E. KRISCH

Authors

  1. Search for ROBERT E. KRISCH in:

About this article

Publication history

Received

Revised

Issue Date

DOI

https://doi.org/10.1038/2221295a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.