Abstract
THE mechanism of the rapid increase in specific antibody-producing cells during the primary immune response may involve cell division, cell “recruitment”, or a combination of both. The use of mitotic blocking agents has indicated that very rapid cell division, stimulated by antigen, alone accounts for the rapid increase in haemolytic plaque-forming cells during the primary response by the mouse to sheep erythrocytes1. Several autoradiographic studies were also interpreted to indicate an antigen-stimulated increase in the rate of division by plaque-forming cells during the primary response2,3. One group has, however, interpreted its own and other autoradiographic data to indicate that antigen does not stimulate more rapid division by plaque-forming cells4,5. Two of these studies2,5 involved examination of plaque-forming cells only, sampled on one day. The other two studies3,4 were severely limited in sensitivity by the technique for examining DNA synthesis—continuous exposure to 3H-thymidine from the time of antigen administration to the time of death.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rowley, D. A., Fitch, F. W., et al., J. Exp. Med., 127, 983 (1968).
Koros, A. M. C., Fuji, H., and Jerne, N. K., Fed. Proc., 25, 305 (1966, abstract).
Szenberg, A., and Cunningham, A. J., Nature, 217, 747 (1968).
Tannenberg, W. J. K., Nature, 214, 293 (1967).
Tannenberg, W. J. K., and Malaviya, A. N., J. Exp. Med., 128, 895 (1968).
Mishell, R. I., and Dutton, R. W., Science, 153, 1004 (1966).
Barka, T., and Anderson, P. J., Histochemistry, 106 (Hoeber, New York, 1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KRISCH, R. DNA Synthesis by Antibody-forming Cells during the Primary Immune Response. Nature 222, 1295–1296 (1969). https://doi.org/10.1038/2221295a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2221295a0
This article is cited by
-
Evidence for RNA-DNA Complexes in Haemolytic Plaque-forming Cells containing Ribonuclease Resistant RNA
Nature New Biology (1971)
-
Low protein intake and response toEscherichia coli 055 infection in patas monkeys
The American Journal of Digestive Diseases (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.